Distribution of common syndrome elements of disease nature in 801 patients with viral hepatitis cirrhosis：a comparison between compensation stage and discompensation stage
10.3969/j.issn.1006-2157.2015.04.009
- VernacularTitle:801例肝炎肝硬化患者常见病性类证候要素在代偿期及失代偿期的分布特点?
- Author:
Li-Hong ZHAO
1
;
Tian-Fang WANG
;
Xiao-Lin XUE
;
Xiu-Yan WU
;
Ning LI
;
Yong-Gang LI
;
Xin LI
;
Sheng-Duo CHEN
;
Feng-Xia SUN
;
Xiu-Hui LI
;
De-Wen MAO
;
Yan-Ling LIU
;
ZHANG-Chang
;
Wen LIU
;
Qiu-Yun ZHANG
Author Information
1. 北京中医药大学 北京100029
- Keywords:
viral hepatitis cirrhosis;
syndrome elements of disease nature;
distribution
- From:
Journal of Beijing University of Traditional Chinese Medicine
2015;(4):260-265
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discover the rules of distribution and combination of common syndrome elements in vital hepatitis cirrhosis( VHC) patients based on the method of combination of syndrome and diseases, so as to guide the TCM clinical practice. Methods A national multicenter and cross-section epidemiological survey was conducted by using Information Collection form of Vital Hepatitis Cirrhosis drafted by the research group to collect the TCM symptoms, tongue manifestation and pulse condition . Based on consensuses on clinical diagnosis and treatment of VHC literature review, Standard of Hepatitis Cirrhosis Syndrome Elements Differentiation was established after two-round experts approval, on which the syndrome elements of 801 patients were determined. Descriptive statistics and Chi-square test were applied. Results Altogether 7 syndrome elements of disease nature lied in 801 patients with viral hepatitis cirrhosis:517 cases of qi deficiency, 503 cases of blood stasis, 462 cases of water retention, 448 case of yin deficiency, 438 cases of qi stagnation, 428 cases of yang deficiency and 257 cases of damp heat, in addition, the frequency of qi deficiency, blood stasis, damp heat and yang deficiency was higher at discompensation stage than that of the compensation stage ( P < 0. 05 ) . In 314 patients of compensation stage, the frequency of blood stasis (36. 36%) , qi deficiency&qi stagnation(20. 00%) , qi deficiency & yin deficiency & blood stasis ( 11. 32%) , qi deficiency & yang deficiency & yin deficiency & qi stagnation ( 16. 13%) and qi deficiency & yang deficiency & yin deficiency & qi stagnation & blood stasis(45. 1%) was the highest in distribution of single and combination of syndrome elements, respectively. In 487 patients of discompensation stage, the frequency of water retention (90. 91%), qi deficiency & water retention(57. 45%), qi deficiency & blood stasis & water retention (26. 44%) , qi deficiency & yang deficiency & blood stasis & water retention ( 23. 40%) and qi deficiency&yang deficiency&qi stagnation&blood stasis&water retention(25. 00%) was the highest, respectively. With regard to combination of six types of syndrome elements, water retention was not included in 60. 00% patients at compensation stage, and damp heat was not included in 59. 61% patients at discompensation stage. Conclusion Single type of element and combinations of two, three, four or five types of syndrome elements were more in patients of compensation, by contrast, combination of three, four, five, six or seven types of elements were more in patients of discompensation. Qi deficiency and blood stasis were the basic pathogenesis in patients of compensation and discompensation stage, and pathogenesis features showed differently at different stages.
