Influences of tenuigenin on learning and memory ability and neurotransmitters in senescence-accelerated mice
- VernacularTitle:远志皂苷对快速脑老化鼠学习记忆能力的改善及对神经递质的影响
- Author:
Lu ZHENG
1
;
Le QIU
;
Yao ZHANG
;
Tian-Jiao FENG
;
Jian-Chun YU
;
Zhan-Jun ZHANG
Author Information
1. 北京师范大学
- Keywords:
tenuigenin;
senescence;
learning and memory;
neurotransmitters;
mice
- From:
Journal of Beijing University of Traditional Chinese Medicine
2010;33(3):183-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the improving effect of tenuigenin on learning and memory ability and its influence on cerebral monoamine neurotransmitters in senescence-accelerated mice prone 8(SAMP8).Methods The senescence-accelerated mice(SAMP8)were chosen as subjects,and then randomly divided into the model group,tenuigenin group and Donepezil group.SAMR1 were chosen into the the control group.After intragastrical treatment for 3 months,the learning and memory ability and the levels of 5-hydroxytryptamine(5-HT),5-hydroxyindoleacetic acid(5-HIAA),dopamine(DA)and norepinephrine(NE)were detected respectively by applying Morris water maze and high performance liquid chromatography(HPLC).Results In the tenuigenin group the hidden platform test showed that the escape latency was,respectively,(43.56±10.87)s,(41.37±9.71)s,(37.62±10.05)s and (41.60±13.61)s from the 2nd to 5th day,and the reversed test showed that the escape latency was (37.10±14.04)s on the 9th day,which were all shortened compared with those in the model group,and the difference was statistically significant(P＜0.05).In the tenuigenin group the level of 5-HT,5-HIAA,DA or NE was,respectively,(5.95±0.93)mmol/L,(4.43±1.08)mmoL/L,(2.61±0.87)mmol/L and(9.44±3.76)mmol/L,which all increased compared with those in the model group,and the difference was statistically significant(P＜0.05).Conclusion Tenuigenin can improve the learning and memory ability of SAMP8,and the effect may related to that it can regulate the level of cerebral monoamine neurotransmitters.
