Pharmacological effects of different extract fractions from Guijianyu(Euonymus alatus)on diabetic rats
- VernacularTitle:鬼箭羽不同提取部位对糖尿病大鼠药理作用的研究
- Author:
Yu-Jie LI
1
;
Mu-Xin GONG
;
Yuan-Yuan LAI
;
Qian WANG
;
Yun-Hua CHEN
;
Peng-Fei TIAN
Author Information
1. 北京中医药大学
- Keywords:
Guijianyu(Euonymus alatus);
diabetes;
hemobiochemistry;
hemorrheology;
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2010;33(3):179-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the Pharmacological effects of different extract fractions from Guijianyu (Euonymus alatus)on diabetic rats,pursue the effective fractions,make clear the effective constituents of Guijianyu for treating diabetes,and set up the quality control standard.Methods The model of diabetic rat was established by the injection of streptozotocin(sax).All rats were divided into the model group,treatment group and normal group.The treatment group was given the fractions of Guijianyu including petroleum ether,ethyl acetate,n-butyl alcohol,water,residue and rectified polysaccharide respectively.After 4 weeks the body weight,blood sugar(BS),blood fat,creatinine,urea,and whole blood viscosity(WBV)and whole blood reduced viscosity at high or low share rate were observed.Results The fractions of petroleum ether,water and ethyl acetate had significant anti-diabetes effect,n-butyl alcohol and rectified polysaccharide had significant reducing effect on blood creatinine,and other fractions had significant reducing effect on urea.The fraction of residue decreased significantly the content of low-density hpoprotein(LOL)and cholesterol(CH),water decreased WBV,and rectified polysaccharide increased significantly hematocrit(HCT).The body weight was put on by all ffactiom except rectified polysaccharide.Conclusion Different fractions of Guijianyu have different effects in anti-diabetes,anti-hyperlipidemia,improving kidney function,decreasing blood viscosity and putting on body weight.Guijianyu can be used for curing and preventing diabetes and its complications through influencing different links in the development of diabetes.
