Influences of Shenyanning on renal signal pathway of TGF-β_1 and p38MAPK in rats with IgA nephropathy
- VernacularTitle:肾炎宁对IgA肾病大鼠TGF-β_1/p38 MAPK的影响
- Author:
Deng-Zhou GUO
1
;
Yue-Hua WANG
;
Dong BIAN
;
Zhi-Qiang CHEN
;
Pei-Ying HAN
;
Yue-Fang JIN
Author Information
1. 河北医科大学
- Keywords:
Shenyanning;
IsA nephropathy;
transforming growth factor-β_1;
038 mitogen activated protein kinase;
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2010;33(3):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the influences of Shenyanning on renal signal pathway of transforming growth factor-β_1(TGF-β_1)and p38 mitogen activated protein kinase(p38MAPK)in rats with IgA nephropathy.Methods All SD rats were randomly divided into the control group,model group,Western medicine group(benazepril and losartan),and Chinese medicine group(Shenyanning).The model of IgA nephropathy was established by the method of lipopolysaccharide+bovine albumin+carbon tetrachloride.All groups were given relevant drugs intragastrically.The expressions of TGF-β_1 and p38MAPK-mRNA were detected by applying IgA immunofluorescence test and RT-PCR at the end of the 15th week.Results The strength of IgA immunofluorescence and expressions of TGF-β_1 and p38MAPKmRNA decreased significantly in the Chinese medicine group and Western medicine group compared with those in the model group(P＜0.05).Conclusion Shenyanning may cure IgA nephropathy through inhibiting renal signal pathway of p38MAPK.
