Influences of acupotomy therapy on ethology and morphology of rabbit model of knee osteoarthritis
- VernacularTitle:针刀松解法对兔膝骨关节炎模型行为学和形态学的影响的实验研究
- Author:
Yi QIN
1
;
Qing-Guo LIU
;
Wei-Lan QIN
;
Yong-Yun FU
;
Gui-Gang ZENG
;
Bo JI
;
Chang-Qing GUO
Author Information
1. 北京中医药大学
- Keywords:
knee osteoarthritis;
acupotomy therapy;
rabbits;
Lequesne algofunctional index;
transmission electron microscope;
rabbits
- From:
Journal of Beijing University of Traditional Chinese Medicine
2010;33(1):64-67,后插4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathogenesis of osteoarthritis and feasibility of acupotomy therapy through the observation on the influences of acupotomy therapy on ethology and morphology in rabbits with knee osteoarthritis.Methods The model of knee osteoarthritis was established by applying the fixed method of knee extension posture in rabbits. The therapy of electro-acupuncture and acupotomy therapy were used to treat the rabbits. After 3 weeks the knee joint function was observed and reviewed based on Lequesne algofunctional index. The light microscope was used to observe tibia tissue after HE staining. The transmission electron microscope (TEM) was used to observe the internal femoral condyle cartilage.Results Lequesne algofunctional index showed that in local reaction, gait reaction and joint motion there was a significant different between the electro-acupuncture group or acupotomy group and the normal group or model group (P<0.05), respectively, while there was no different between the electro-acupuncture group and acupotomy group (P>0.05). HE staining showed that the cartilage injury was relieved and tended to recovery in the electro-acupuncture group and acupotomy group. The result of TEM showed that the lesion of cartilage cells and disorder of collagen fibrils were relieved in the acupotomy group, which is similar to those in the electro-acupuncture group.Conclusion The acupotomy therapy has a good curative effect on knee osteoarthritis, which is proved at macroscopic and microscopic levels.
