Antagonism of GBE50 on lesion of myocardial ischemia-reperfusion observed with myocardial mechanics
- VernacularTitle:从心肌力学观察银杏酮酯抗心肌缺血再灌注损伤的作用
- Author:
Yi-Min BAO
1
;
Zhi-Xiong ZHANG
Author Information
1. 上海中医药大学
- Keywords:
myocardial mechanics;
hemodynamics;
lesion of myocardial ischemia-reperfusion;
extract of Ginkgo biloba (GBE50);
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2010;33(1):28-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the preventive effect of extract of Ginkgo biloba (GBE50) on the le-sion of myocardial ischemia-reperfusion (I/R) in vitro in rats, and discuss the evaluation functions of myocardial mechanics and hemodynamics information.Methods SD rats (n=55) were randomly divided into 6 groups including the model group, high-dose, mid-dose and low-dose GBE50 groups, Danshen (Radix Salviae Miltiorrhizae) group and diltiazem group. All groups were given Langendorff heart perfusion in vitro for 15 minutes. The perfusion was stopped for 30 minutes to induce global ischemia and then reperfusion was given in all groups for 40 minute. The left ventricular pressure was recorded and the influences of different drugs on the changes of myocardial mechanics and hemodynamics were observed.Results After I/R the levels of heart rate (HR), mLVSP, developed pressure (DP) and ±dp/dt_(max) were all lower than those before I/R, and the levels of mLVDP and t-dp/dt_(max) increaed significantly (P<0.05 to P<0.001). Along with the prolongation of reperfusion time all indexes tended to normal level. The levels of DP and ±dp/dt_(max) were higher (P<0.05) and t-dp/dt_(max) and mLVDP were lower (P<0.05) significantly in the mid-dose GBE50 group, Danshen group and diltiazem group than those in the model group.Conclusion GBE50 has a significant preventive effect on heart function decline induced by the lesion of myocardial ischemia-reperfusion. The evaluation with myocardial mechanics and hemodynamics is stable and reliable.
