Association of serum gamma-glutamyl transferase levels with cardiovascular disease risk in type 2 diabetes patients: a prospective cohort study
10.3760/cma.j.cn112338-20240628-00384
- VernacularTitle:血清γ-谷氨酰转肽酶水平与2型糖尿病患者心脑血管疾病风险的前瞻性队列研究
- Author:
Mian WANG
1
;
Xikang FAN
;
Jian SU
;
Yu QIN
;
Chong SHEN
;
Yan LU
;
Zhongming SUN
;
Jie YANG
;
Ran TAO
;
Jinyi ZHOU
;
Ming WU
Author Information
1. 南京医科大学公共卫生学院，南京 211166
- Keywords:
Diabetes mellitus, type 2;
Serum gamma-glutamyl transferase;
Cardiovascular disease;
Prospective study
- From:
Chinese Journal of Epidemiology
2024;45(10):1339-1347
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the associations of serum gamma-glutamyl transferase (GGT) levels with the risk of cardiovascular disease (CVD) and its subtypes in patients with type 2 diabetes mellitus (T2DM) in Jiangsu Province.Methods:The participants were enrolled in the Comprehensive Research project regarding 'Prevention and Control of Diabetes' in Jiangsu Province. The baseline survey was conducted from 2013 to 2014, and follow-up until December 31, 2021. After excluding the participants who self-reported with chronic liver disease/stroke/coronary heart disease at baseline survey and those with incomplete information on GGT, a total of 16 147 T2DM patients were included in the final analysis. Cox proportional hazard regression models were used to calculate the hazard ratio ( HR) and their 95% CI of GGT for CVD, myocardial infarction, and stroke. Restricted cubic spline models were applied to analyze the dose-response relationship between GGT and the risk of CVD and its subtypes. Results:During the median follow-up time of 8.02 years, 2 860 CVD cases were registered, including 196 cases of myocardial infarction and 2 730 cases of stroke. Multivariate Cox proportional risk regression model indicated that compared to the lowest serum GGT level group, the highest GGT level group had a 24% increased risk of CVD ( HR=1.24, 95% CI: 1.09-1.41) and a 23% increased risk of stroke ( HR=1.23, 95% CI: 1.08-1.40). The restricted cubic spline model showed a nonlinear dose-response relationship between GGT and the risk of CVD, myocardial infarction, and stroke in T2DM patients. Conclusions:High levels of GGT may be associated with an increased risk of cardiovascular disease in T2DM patients, which needs further exploration and validation in future clinical practice.
