Hemorrheology mechanism of cerebral infarction induced by sudden rise of temperature
- VernacularTitle:骤然升温导致脑梗塞发病的血液流变学机制研究
- Author:
Xiao-Yan LIU
1
;
Xia-Zhen GUO
;
Yun-Shuang YANG
;
Li-Hua LI
Author Information
1. 北京中医药大学
- Keywords:
sudden rise of temperature;
cerebral infarction;
correspondence between nature and human;
hemorrheology;
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2010;33(1):23-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the hemorrheology mechanism of cerebral infarction induced by sudden rise of temperature in hypertensive rats based on TCM doctrine of correspondence between nature and human.Method The model of stroke-prone renovascular hypertension (RHRSP) was put into artificial circumstance of sudden rise of temperature for inducing cerebral infarction. The changes of hemorrheology indexes were detected before and after the sudden rise of temperature.Result The whole blood viscosity, erythrocyte aggregation index (EAI), erythrocyte electrophoresis index (EEI), hematocrit (Hct) and erythrocyte rigidity index (ERI)all increased when the temperature rose suddenly, especially in the mod-el group. After the rise of temperature the whole blood viscosity decreased in the physical group and sham-operation group but tended to increased in the model group (P<0.05 or P<0.01). The whole blood viscosity, EAI, EEI and ERI were all higher in the model group than those in the physical group and sham-operation group at the same time point (P<0.05 or P<0.01) after the rise of temperature.Conclusion The onset of cerebral infarction induced by sudden rise of temperature is not related to the increase of the whole blood viscosity and slowed blood flow. It depends on that a long-term pathological base with hypertension mainly destroys the self regulation of the body for adapting surrounding changes. The body cannot return to the normal physical state after the continuous increase of blood viscosity stimulated by a higher temperature.
