Stability of salvianolic acid B in water solution

VernacularTitle:丹酚酸B在水溶液中的稳定性研究
Author: Wen-Xin ZHANG ¹ ; Lv XUAN ; Jian NI
Author Information

1. 北京中医药大学
Keywords: Danshen(Radix Salviae Miltiorrhizae); salvianolic acid B; temperature; stability
From: Journal of Beijing University of Traditional Chinese Medicine 2009;32(12):856-858
CountryChina
Language:Chinese
Abstract: Objective To study the influence of temperature on the stability of salvianolic acid B in water solution.Methods The content changes of salvianolic acid B in control solution and water extract solution of Danshen(Radix Salviae Miltiorrhizae)were observed by applying the classic isothermal accelerated test.The results were compared in two experimental conditions.The order of reaction of salvianolic acid B along with temperature degradation was determined through mapping natural logarithm and time(lnC-t),and t_(1/2) and t_(0.9) were predicted at different temperature.Results In two experimental conditions the content of salvianolic acid B accorded with the first-order kinetics equation with the changes of temperature.When temperature increased the content of salvianolic acid B decreased.The degradation speed of salvianolic acid B was higher in the control solution than that in the water extract solution of Danshen.Conclusion The stability of salvianolic acid B is very different at different temperature,which needs more attention in preparing course of the preparation containing salvianolic acid B.