Ethological changes in rats with chronic stress-induced anxiety and interventional effect of Danzhixiaoyao Powder
10.3321/j.issn:1006-2157.2009.12.009
- VernacularTitle:慢性焦虑应激大鼠行为学的变化及中药丹栀逍遥散的干预作用
- Author:
Ning LI
1
;
Qi-Sheng TANG
;
Rui-Zhen ZHAO
;
Sheng-Le GOU
Author Information
1. 北京中医药大学
- Keywords:
anxiety model;
ethology;
chronic emotion tress;
Danzhxiaoyao Powder;
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2009;32(12):826-829
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the interventional effect of Danzhixiaoyao Powder from the aspect of ethology in rats with chronic stress-induced anxiety.Methods The rat model of chronic stress-induced anxiety was established by using the stimulation of uncertainty empty bottle.The changes of exploratory,grooming and attack behaviors were observed when rats were stimulated by empty bottle.After the stress the ethology of rats were reviewed by applying international elevated plus-maze(EPM)test.The interventional effect of Danzhxiaoyao Powder was observed.Results The rats were irritable after the stress and had frequency grooming and attack behaviors.The result of EPM test showed that the rats were not wiBing to enter or stay in the open arm,but tended to explore the block arm and stay in there for a longer time.The motor activity of the rats decreased.After the intervene of Danzhixiaoyao Powder the grooming and attack behaviors of rats were reduced significantly,the total motor activity increased,and exploring times and stay time in the open ann were improved.Conclusion The model of chronic psychological stress by the stimulation of uncertainty empty bottle simulates well the anxiety in rats etiologically.Danzhxiaoyao Powder has a significant anti-anxiety effect.
