Influence of Siwu Mixture on metabolism in rats after chemotherapy by applying NMR metabonomics technique

VernacularTitle:利用核磁共振代谢组学技术研究四物合剂对化疗后大鼠代谢的影响
Author: Yun-Zhi CHEN ¹ ; Xiao-Ou XUE ; Jian-Zhao NIU ; Li-Ping SUN
Author Information

1. 北京中医药大学东直门医院
Keywords: Siwu Mixture; Cisplatin; metabonomics; nuclear magnetic resonance; rats
From: Journal of Beijing University of Traditional Chinese Medicine 2009;32(11):751-754
CountryChina
Language:Chinese
Abstract: Objective To study the influence of Siwu Mixture on metabolites in rats after the intraperitoneal injection of chemotherapeutics-Cisplatin.Method The rats (n=6) were randomly divided into the experimental group, model group and normal group (each n=2). The experimental group and model group were respectively given Siwu Mixture and purified water intragastrically after the intraperitoneal injection of Cisplatin, and the normal group was given purified water intragastrically after the injection of normal saline solution. The urine were collected from the rats in all groups every day and the spectroscopy of 1H-nuclear magnetic resonance (1H-NMR) was determined.Result After multivariate statistical analysis the metabolites of the experimental group, model group and normal group were different significantly, especially acetic acid, alanine, lactic acid and hippuric acid.Conclusion The result of the study indicates that Siwu Mixture can protect the functions of the liver and kidney.