Dynamic observation on interventional effect of Naoshuning on traumatic brain edema in rats by using MRI
10.3321/j.issn:1006-2157.2009.11.007
- VernacularTitle:应用磁共振显像动态观察脑疏宁对大鼠创伤脑水肿的干预作用
- Author:
Xiang-Ning CUI
1
;
Ming LIU
;
Jing ZHAO
;
Yu-Lai WANG
;
Yong-Lie ZHAO
Author Information
1. 卫生部中日友好医院
- Keywords:
traumatic cerebral edema;
magnetic resonance imaging;
Naoshuning;
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2009;32(11):747-750,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the effect of Naoshuning on brain edema through observing the dynamic changes of magnetic resonance imaging (MRI) in rats with brain contusion and laceration.Methods All 114 male SD rats were randomly divided into Naoshuning group, model group and sham-operation group. The rat model of brain contusion and laceration was established by free-falling impact according to Feeney's method. After the operation the dynamic changes of MRI signal intensity (SI) and volume in T_2 WI focus were observed consecutively, and the brain water content was determined by using dry-wet method.Results There were changes observed in increased SI of T_2 in the cerebral hemisphere with operation. SI got the highest level and volume on the first day and then decreased gradually and reached the lowest level on the seventh day, which showed a parallel course with brain water content. In Naoshuning group SI in T_2 WI focus, edema volume and brain water content were significantly lower than those in the model group at all time points (P<0.05). The absorption rate of edema in Naoshuning group was significantly higher than that in the model group (P<0.005) seven days after the operation.Conclusion The non-invasive MRI examination can be used to analyse quantitatively the degree of brain trauma and edema in rats after the treatment with Naoshuning, which is reliable for review the curative effect. Naoshuning can improve the absorption of edema after brain contusion and laceration.
