A cohort study of maternal smoking during pregnancy, offspring genetic risk, and overall cancer mortality
10.3760/cma.j.cn112338-20240221-00078
- VernacularTitle:母亲孕期吸烟及子代遗传风险与全肿瘤死亡风险的队列研究
- Author:
Guanlian PANG
1
;
Zhimin MA
;
Mingxuan ZHU
;
Wenjing GE
;
Yuanlin MOU
;
Guoqing WANG
;
Zhaopeng ZHU
;
Qiao LI
;
Meng ZHU
Author Information
1. 南京医科大学公共卫生学院流行病学系，南京 211166
- Keywords:
Maternal smoking during pregnancy;
Polygenic risk score;
Overall cancer mortality;
Prospective cohort study
- From:
Chinese Journal of Epidemiology
2024;45(8):1045-1051
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the independent and combined effects of maternal smoking during pregnancy and offspring genetic susceptibility on overall cancer mortality.Methods:Based on the United Kingdom Biobank ( n=419 228) data, the Cox proportional hazard regression model was used to estimate the effect of maternal smoking during pregnancy on offspring overall cancer (including 16 cancers in men and 18 in women) mortality and its combined effect and interaction with offspring genetic factors. Results:Maternal smoking during pregnancy was significantly associated with a 13% increased risk of overall cancer mortality in men [hazard ratio( HR)=1.13, 95% CI: 1.06-1.20] and 19% increased risk in women ( HR=1.19, 95% CI: 1.11-1.27). Participants with high genetic risk had the highest overall cancer mortality than those with low genetic risk (men: HR=1.42, 95% CI: 1.30-1.55; women: HR=1.38, 95% CI: 1.25-1.52). Compared with participants without maternal smoking during pregnancy and low genetic risk, those with maternal smoking during pregnancy and high genetic risk were associated with a 56% increased risk of overall cancer mortality in men ( HR=1.56, 95% CI: 1.37-1.77) and 59% in women ( HR=1.59, 95% CI: 1.39-1.83). Conclusion:Maternal smoking during pregnancy may increase offspring overall cancer mortality and more severe harm in individuals with high genetic risk.
