Influences of Jiangyamaijing Solution on inflammatory factors and left ventricular remodeling in rats with spontaneously hypertension
10.3321/j.issn:1006-2157.2009.10.012
- VernacularTitle:降压脉净液对自发性高血压大鼠炎性因子及左室重构的影响
- Author:
Lin LI
1
;
Tai-Ling WANG
;
Lin PAN
;
Cheng XIAO
;
Hong LI
;
Wang CHEN
;
Li HUANG
Author Information
1. 卫生部中日友好医院
- Keywords:
hypertension;
Jiangyamaijing Solution;
left ventricular remodeling;
interleuking-6;
tumor necrosis factor-α;
rats
- From:
Journal of Beijing University of Traditional Chinese Medicine
2009;32(10):695-698,705,彩页2
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of inflammatory reaction on the left ventricular remodeling induced by spontaneously hypertension, and to discuss the intervene of Jiangyamaijing Solution. Methods The rats with spontaneously hypertension (8 weeks old, n = 40) were randomly divided into the normal control group ( group A) , model group ( group B) , treatment group treated with Jiangyamaijing Solution and Luohuoxi Tablets orally ( group C) , Western medicine control group treated with Luohuoxi Tablets orally (group D) and Chinese medicine control group treated with Niuhuangjiangya Pills and Luohuoxi Tablets orally (group E). One treatment course was 20 weeks. The blood pressure and pathological changes were observed, the heart weight index ( HWI) , myocardial interstitial collagen volumetric fraction (CVF) and perivascular collagen area (PVCA) were calculated, and the expressions of serum interleuking-6 ( IL-6) and tumor necrosis factor-a (TNF-α) were detected by using radioimmunoassay. Results ① In group D the cardiomyocyte hypertrophy and myocardial interstitial inflammatory cell infiltration were relieved and collagen content was reduced significantly ( P < 0. 01). HWI had a trend of descent. ②The expressions of serum IL-6 and TNF-a were higher significantly ( P < 0.01) in rats with spontaneously hypertension than those in normal rats. ③In group D the expression of serum IL-6 decreased significantly compared with that in group B and the effect was better than that in other groups (P < 0. 01). Conclusions The excess expressions of serum IL-6 and TNF-α may be involved in the left ventricular remodeling induced by spontaneously hypertension. The remodeling can be reversed by Jiangyamaijing Solution and the mechanism may be related to the decrease of IL-6 expression.
