Prospective association study of sleep status and risk of coronary heart disease in adults in Suzhou
10.3760/cma.j.cn112338-20231215-00356
- VernacularTitle:苏州市成年人睡眠状况与冠心病发病风险的前瞻性关联研究
- Author:
Jiang HUA
1
;
Xikang FAN
;
Jian SU
;
Lulu CHEN
;
Yan LU
;
Yujie HUA
;
Hongfu REN
;
Pei PEI
;
Dianjianyi SUN
;
Canqing YU
;
Jun LYU
;
Jinyi ZHOU
;
Ran TAO
Author Information
1. 南京医科大学公共卫生学院，南京 211166
- Keywords:
Sleep status;
Coronary heart disease;
Prospective study
- From:
Chinese Journal of Epidemiology
2024;45(7):914-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between sleep status and the risk for coronary heart disease in adults in Suzhou.Methods:Using the baseline and follow up information of 53 269 local residents aged 30-79 years in China Kadoorie Biobank conducted in Wuzhong District, Suzhou, 51 929 subjects were included in this study after excluding those reporting coronary heart disease, stroke and cancer at the baseline survey. A Cox proportional hazards regression model was used to analyze the association of healthy sleep score (0-3 points) and sleep factors (snoring, insomnia, long sleep duration and nap) with the risk for coronary heart disease.Results:The median follow-up time was 11.12 years, and 1 304 individuals were diagnosed with coronary heart disease during the follow-up. After adjusting for potential confounders, occasional snoring ( HR=1.20, 95% CI: 1.04-1.38), usual snoring ( HR=1.17, 95% CI: 1.02-1.33), insomnia disorder ( HR=1.41, 95% CI: 1.12-1.78), daytime dysfunction ( HR=1.56, 95% CI: 1.20-2.03) and perennial nap ( HR=1.37, 95% CI: 1.19-1.59) were associated with increased risk of coronary heart disease. Compared with those with sleep score of 0 - 1 (low sleep quality), the people with sleep score of 3 had reduced risk of coronary heart disease by 26% ( HR=0.74, 95% CI: 0.63-0.87). Stratified analysis showed that the association of healthy sleep score 3 with risk of coronary heart disease was stronger in low physically active individuals (interaction P<0.05). Conclusions:Snoring, insomnia disorders, daytime dysfunction, and perennial napping were all associated with increased risk for coronary heart disease, and keep healthy sleep mode might reduce the risk for coronary heart disease in adults.
