Effects of Huadaixingshen Decoction on the Pathological Changes and Cholinergic Fibers in the Rats with Vascular Dementia
10.3321/j.issn:1006-2157.2001.03.009
- VernacularTitle:化呆醒神汤对大鼠血管性痴呆模型病理变化及胆碱能纤维的影响
- Author:
Li ZHANG
1
;
Hongtu WANG
Author Information
1. Beijing University of Traditional Chinese Medicine
- From:
Journal of Beijing University of Traditional Chinese Medicine
2001;24(3):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Rat vascular dementia model was established by the repeated cerebral ischemia reperfusion method, and the model rats were treated with Huadaixingshen Decoction (HD) with the administration of hydergine as contrast. The results of the observation with the optical microscope and the electron microscope showed that in the rats of the model group, a large number of neurons in the hippocampal CA1 area exhibited degeneration, necrosis and deletion, mitochondrial tumefaction, vacuolar degeneration and synaptic degeneration; and the tissue staining and quantitative analysis found that the number of AchE-positive fibers in the hippocampal CA1 area and the frontal cortex obviously decreased. It was shown that HD could obviously reduce the neuronal injury in the hippocampal CA1 area, and increase the number of AchE-positive fibers in the hippocampal CA1 area and the frontal cortex, and its effects were better than those of hydergine.
