Analysis on disease burden of digestive system cancers in population in China
10.3760/cma.j.cn112338-20231102-00270
- VernacularTitle:中国人群消化系统癌症疾病负担分析
- Author:
Zhangyan LYU
1
;
Wenxuan LI
;
Guojin SI
;
Yacong ZHANG
;
Mengbo XING
;
Yubei HUANG
;
Ben LIU
;
Fangfang SONG
;
Fengju SONG
;
Kexin CHEN
Author Information
1. 天津医科大学肿瘤医院流行病与生物统计学研究室/天津市肿瘤分子流行病重点实验室/人群重大疾病防控教育部重点实验室/国家恶性肿瘤临床医学研究中心/天津市恶性肿瘤临床医学研究中心，天津 300060
- Keywords:
Cancer;
Digestive system;
Mortality;
Disability-adjusted life years;
Risk factors
- From:
Chinese Journal of Epidemiology
2024;45(5):633-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the incidence and mortality of digestive system cancers, and the trend of the disease burden attributed to different risk factors in population in China.Methods:Data were obtained from the GLOBOCAN 2020 and the Global Burden of Disease Study in 2019 databases and only the data from the Chinese population were included. Using Excel 2019 and R 4.2.1 software, indicators including age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), age-standardized disability-adjusted life year (DALY) rate and its rate of change were used to illustrate the disease burden of digestive system cancers attributed to different factors and their trends.Results:In 2020, the ASIR of digestive system cancers in China was 83.00/100 000, and the ASMR was 63.80/100 000. The numbers of digestive system cancer cases and deaths increased with age, and more cases and deaths occurred in men than in women in all age groups. The age-standardized DALY rate of esophageal cancer, gastric cancer and liver cancers showed decreasing trends in China from 1990 to 2019 (rate of change: -45.26%, -46.87%, and -65.63%, respectively), whereas the age-standardized DALY rate of pancreatic cancer, colorectal cancer and gallbladder and biliary tract cancer showed increasing trends (rate of change: 67.61%, 30.52%, and 7.21%, respectively). The trend of the mortality rate was consistent with the DALY rate. Compared with the age-standardized DALY rate attributed to behavioral factors, the annual proportion of the age-standardized DALY rate attributed to metabolic factors to the total age-standardized DALY rate of esophageal cancer, liver cancer, pancreatic cancer, and colorectal cancer increased from 1990 to 2019. There was no significant change in the rank of age-standardized DALY rate of gastric cancer, liver cancer, pancreatic cancer, and gallbladder and biliary tract cancer attributed to different risk factors in China from 1990 to 2019, but the rank of certain attributed risk factors for the age-standardized DALY rate of esophageal cancer and colorectal cancer moved ahead (esophageal cancer: high BMI; colorectal cancer: low milk intake, and low whole-grain intake).Conclusions:The incidence and mortality of digestive system cancers was serious in China in 2020, and the annual proportion of the disease burden of digestive system cancers attributed to metabolic factors increased from 1990 to 2019. The rank of attributed risk factors for several digestive system cancers changed significantly.
