Associations of onset age, diabetes duration and glycated hemoglobin level with ischemic stroke risk in type 2 diabetes patients: a prospective cohort study
10.3760/cma.j.cn112338-20231009-00210
- VernacularTitle:2型糖尿病患者发病年龄、病程、糖化血红蛋白与缺血性脑卒中发病风险的前瞻性队列研究
- Author:
Xikang FAN
1
;
Mengyao LI
;
Yu QIN
;
Chong SHEN
;
Yan LU
;
Zhongming SUN
;
Jie YANG
;
Ran TAO
;
Jinyi ZHOU
;
Dong HANG
;
Jian SU
Author Information
1. 江苏省疾病预防控制中心，南京 210009
- Keywords:
Diabetes mellitus, type 2;
Ischemic stroke;
Prospective study
- From:
Chinese Journal of Epidemiology
2024;45(4):498-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the associations of onset age, diabetes duration, and glycated hemoglobin (HbA1c) levels with ischemic stroke risk in type 2 diabetes patients.Methods:The participants were from Comprehensive Research on the Prevention and Control of the Diabetes in Jiangsu Province. The study used data from baseline survey from December 2013 to January 2014 and follow-up until December 31, 2021. After excluding the participants who had been diagnosed with stroke at baseline survey and those with incomplete information on onset age, diabetes duration, and HbA1c level, a total of 17 576 type 2 diabetes patients were included. Cox proportional hazard model was used to calculate the hazard ratio ( HR) and 95% CI of onset age, diabetes duration, and HbA1c level for ischemic stroke. Results:During the median follow-up time of 8.02 years, 2 622 ischemic stroke cases were registered. Multivariate Cox proportional risk regression model showed that a 5-year increase in type 2 diabetes onset age was significantly associated with a 5% decreased risk for ischemic stroke ( HR=0.95, 95% CI: 0.92-0.99). A 5-year increase in diabetes duration was associated with a 5% increased risk for ischemic stroke ( HR=1.05, 95% CI: 1.02-1.10). Higher HbA1c (per 1 standard deviation increase: HR=1.17, 95% CI: 1.13-1.21) was associated with an increased risk for ischemic stroke. Conclusion:The earlier onset age of diabetes, longer diabetes duration, and high levels of HbA1c are associated with an increased risk for ischemic stroke in type 2 diabetes patients.
