Effect of prenatal stressful life event exposure on child emotional and behavioral problem at age 2-6 years
10.3760/cma.j.cn112338-20230816-00072
- VernacularTitle:孕期应激生活事件暴露水平对儿童2~6岁内情绪与行为问题的影响
- Author:
Jiayi HONG
1
;
Qian WEI
;
Guangzhuang JING
;
Peiqi YE
;
Yuyang SHI
;
Huijing SHI
Author Information
1. 复旦大学公共卫生学院妇幼与儿少卫生教研室，上海200032
- Keywords:
Prenatal;
Stressful life event;
Preschool child;
Emotional and behavioral problem;
Cohort study
- From:
Chinese Journal of Epidemiology
2024;45(3):401-407
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of prenatal stressful life event (SLE) exposure on child emotional and behavioral problem at age 2-6 years and identify the most risk exposure period.Methods:A total of 2 524 mother-child pairs were selected from Shanghai Maternal-Child Pairs Cohort based on pregnant women form 2016 to 2018 in Shanghai. Prenatal SLE exposure was assessed by Life Events Scale for Pregnant Women Questionnaire during the first and third trimester of pregnancy. Child emotional and behavioral problem was evaluated by Strengths and Difficulties Questionnaire at age 2-6 years. Multivariate binary logistic regression model and generalized estimating equation were conducted to quantify the association between prenatal SLE exposure and child emotional and behavioral problem at age 2-6 years, and identify the pregnancy period with strongest adverse effect.Results:The 2 524 mother-child pairs were divided into 4 groups: group with consistent low exposure to SLE (61.8%), group with high exposure to SLE in the first trimester (13.2%), group with high exposure to SLE in the third trimester (13.2%) and group with consistent high exposure to SLE (11.8%). The detection rates of emotional problem, hyperactivity, peer interaction problem and total difficulty score in children aged 3-6 years were highest in the group with consistent high exposure to SLE. Generalized estimating equation analysis showed that after controlling the confounding factors, compared with the consistent low exposure group, the children in the group with high exposure to SLE in the first trimester had significant increased risk for conduct problem at age 2-6 years (a OR=1.41, 95% CI:1.07-1.87). The children in the group with consistent high exposure to SLE were at increased risk for emotional problem, peer interaction problem, and high total difficulty score with the a OR of 1.41 (95% CI: 1.09-1.83), 1.46 (95% CI: 1.15-1.86) and 1.51(95% CI: 1.17-1.93). Conclusion:These findings indicated that prenatal exposure to SLE have adverse effect on child emotional and behavioral problem at age 2-6 years, especially the exposure in the first trimester.
