Incidence of diabetes and influencing factors in HIV-infected individuals after antiretroviral therapy in Dehong Dai and Jingpo Autonomous Prefecture
10.3760/cma.j.cn112338-20230817-00075
- VernacularTitle:德宏傣族景颇族自治州HIV感染者抗病毒治疗后新发糖尿病及影响因素分析
- Author:
Runhua YE
1
;
Yunqiu ZHANG
;
Dongdong CAO
;
Yun SHI
;
Guifang XIAO
;
Pinyin LI
;
Yuanwu XU
;
Hua WEI
;
Jinting SUN
;
Yuecheng YANG
;
Renhai TANG
;
Jibao WANG
;
Na HE
;
Yingying DING
;
Song DUAN
Author Information
1. 德宏傣族景颇族自治州疾病预防控制中心，芒市 678400
- Keywords:
HIV;
Incidence of diabetes;
Influencing factors
- From:
Chinese Journal of Epidemiology
2024;45(3):358-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the incidence of diabetes and influencing factors, the trend of FPG change and risk for mortality in HIV-infected individuals after antiretroviral therapy (ART) in Dehong Dai and Jingpo Autonomous Prefecture (Dehong).Methods:The HIV/AIDS treatment database was collected from China Information System for Disease Control and Prevention. This retrospective cohort study was conducted in HIV-infected individuals with access to ART in Dehong during 2004-2020.The Cox proportional hazard regression model was used to analyze the incidence density of diabetes, the influencing factors and risk for mortality in HIV-infected individuals with access to ART, mixed linear effects model was used to analyze the trend of FPG change and predict FPG in those with different glucose metabolic status at baseline survey. Statistical analysis was performed using software SAS 9.4.Results:A total of 8 763 HIV-infected individuals were included, in whom 8 432 (96.2%) had no diabetes, 331 had diabetes. The incidence density of diabetes was 2.31/1 000 person years. Multivariate Cox proportional hazard regression analysis revealed that 30- 59 years old, BMI ≥24.0 kg/m 2, Efavirenz (EFV) based initial treatment regimen and impaired fasting glucose (IFG) at baseline survey were significantly and positively associated with incidence of diabetes. Mixed effect model revealed that FPG was positively correlated with the duration of ART, age and baseline FPG. Suffering from diabetes was a risk factor for mortality in HIV-infected individuals both at baseline survey and during follow-up. Conclusions:The risk for diabetes increased in HIV-infected individuals who were 30-59 years old, baseline BMI ≥24.0 kg/m 2, received EFV based initial treatment, and IFG in HIV-infected individuals after antiretroviral therapy in Dehong, 2004-2020. It is important to pay close attention to their blood glucose, and patients with high blood glucose should receive treatment as early as possible.
