A prospective study on association between sleep duration and the risk of chronic obstructive pulmonary disease in adults in Suzhou
10.3760/cma.j.cn112338-20230918-00164
- VernacularTitle:苏州市成年人睡眠时长与慢性阻塞性肺疾病发病风险关联的前瞻性研究
- Author:
Mengshi YANG
1
;
Xikang FAN
;
Jian SU
;
Xinglin WAN
;
Hao YU
;
Yan LU
;
Yujie HUA
;
Jianrong JIN
;
Pei PEI
;
Canqing YU
;
Dianjianyi SUN
;
Jun LYU
;
Ran TAO
;
Jinyi ZHOU
Author Information
1. 东南大学公共卫生学院流行病与卫生统计学系，南京 210009
- Keywords:
Chronic obstructive pulmonary disease;
Sleep duration;
Prospective study
- From:
Chinese Journal of Epidemiology
2024;45(3):331-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prospective association of sleep duration with the development of chronic obstructive pulmonary disease (COPD) in adults in Suzhou.Methods:The study used the data of 53 269 participants aged 30-79 years recruited in the baseline survey from 2004 to 2008 and the follow-up until December 31, 2017 of China Kadoorie Biobank (CKB) conducted in Wuzhong District, Suzhou. After excluding participants with airflow limitation, self-reported chronic bronchitis/emphysema/coronary heart disease history at the baseline survey and abnormal or incomplete data, a total of 45 336 participants were included in the final analysis. The association between daily sleep duration and the risk for developing COPD was analyzed by using a Cox proportional hazard regression model, and the hazard ratio ( HR) values and their 95% CI were calculated. The analysis was stratified by age, gender and lifestyle factors, and cross-analysis was conducted according to smoking status and daily sleep duration. Results:The median follow-up time was 11.12 years, with a total of 515 COPD diagnoses in the follow-up. After adjusting for potential confounders, multifactorial Cox proportional hazard regression analysis showed that daily sleep duration ≥10 hours was associated with higher risk for developing COPD ( HR=1.42, 95% CI: 1.03-1.97). The cross analysis showed that excessive daily sleep duration increased the risk for COPD in smokers ( HR=2.49, 95% CI: 1.35-4.59, interaction P<0.001). Conclusion:Longer daily sleep duration (≥10 hours) might increase the risk for COPD in adults in Suzhou, especially in smokers.
