A prospective study of association between physical activity and ischemic stroke in adults
10.3760/cma.j.cn112338-20230904-00125
- VernacularTitle:体力活动与成年人缺血性脑卒中发病关联的前瞻性研究
- Author:
Hao WANG
1
;
Kaixu XIE
;
Lingli CHEN
;
Yuan CAO
;
Zhengjie SHEN
;
Jun LYU
;
Canqing YU
;
Dianjianyi SUN
;
Pei PEI
;
Jieming ZHONG
;
Min YU
Author Information
1. 浙江省疾病预防控制中心慢性非传染性疾病预防控制所，杭州 310051
- Keywords:
Ischemic stroke;
Physical activity;
Prospective study
- From:
Chinese Journal of Epidemiology
2024;45(3):325-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prospective associations between physical activity and incident ischemic stroke in adults.Methods:Data of China Kadoorie Biobank study in Tongxiang of Zhejiang were used. After excluding participants with cancers, strokes, heart diseases and diabetes at baseline study, a total of 53 916 participants aged 30-79 years were included in the final analysis. The participants were divided into 5 groups according to the quintiles of their physical activity level. Cox proportional hazard regression models was used to calculate the hazard ratios ( HR) for the analysis on the association between baseline physical activity level and risk for ischemic stroke. Results:The total physical activity level in the participants was (30.63±15.25) metabolic equivalent (MET)-h/d, and it was higher in men [(31.04±15.48) MET-h/d] than that in women [(30.33±15.07) MET-h/d] ( P<0.001). In 595 526 person-years of the follow-up (average 11.4 years), a total of 1 138 men and 1 082 women were newly diagnosed with ischemic stroke. Compared to participants with the lowest physical activity level (<16.17 MET-h/d), after adjusting for socio-demographic factors, lifestyle, BMI, waist circumference, and SBP, the HRs for the risk for ischemic stroke in those with moderate low physical activity level (16.17-24.94 MET-h/d), moderate physical activity level (24.95-35.63 MET-h/d), moderate high physical activity level (35.64-43.86 MET-h/d) and the highest physical activity level (≥43.87 MET-h/d) were 0.93 (95% CI: 0.83-1.04), 0.87 (95% CI: 0.76-0.98), 0.82 (95% CI: 0.71-0.95) and 0.76 (95% CI: 0.64-0.89), respectively. Conclusion:Improving physical activity level has an effect on reducing the risk for ischemic stroke.
