Association between waist circumference and ischemic stroke: a prospective study in adults from Qingdao
10.3760/cma.j.cn112338-20230911-00146
- VernacularTitle:青岛市成年人腰围与缺血性脑卒中发病风险关联的前瞻性研究
- Author:
Yuhui LI
1
;
Lei LIU
;
Dan HU
;
Xiaoyan ZHENG
;
Jun LYU
;
Canqing YU
;
Pei PEI
;
Haiping DUAN
;
Ruqin GAO
;
Zengchang PANG
;
Xiaocao TIAN
;
Dianjianyi SUN
Author Information
1. 青岛大学公共卫生学院流行病与卫生统计学系，青岛 266071
- Keywords:
Ischemic stroke;
Waist circumference;
Prospective study
- From:
Chinese Journal of Epidemiology
2024;45(2):178-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association between waist circumference (WC) and ischemic stroke (IS).Methods:The data for the present study were from the prospective cohort study of China Kadoorie Biobank in Qingdao. Using baseline information and IS events of the participants, the Cox proportional hazard regression model and restricted cubic spline (RCS) were used to analyze the association between WC and IS.Results:A total of 33 355 participants were included in the study, with 302 008.88 person-years of follow-up. A total of 1 093 new cases of IS were observed. Multivariate Cox proportional hazard regression model analysis showed that compared to the respondents with normal WC (male <85.0 cm, female <80.0 cm), respondents with excessive WC (male ≥85.0 cm, female ≥80.0 cm) had a 78% higher risk of IS incidence [hazard ratio( HR)=1.78, 95% CI: 1.51-2.10], and the risk increased by 72% ( HR=1.72, 95% CI: 1.40-2.12) and 83% ( HR=1.83, 95% CI: 1.40-2.39) in men and women. According to the RCS, the increase in WC and the risk of IS showed an "S" trend of nonlinear dose-response relationship. Conclusions:The risk of IS would increase with the WC. Keeping a normal WC is important for preventing IS.
