Analysis methods and case analysis of effect modification (1): effect modification in epidemiology and traditional Meta-analysis
10.3760/cma.j.cn112338-20230824-00093
- VernacularTitle:效应修饰作用分析方法与案例解析系列（一）：流行病学和经典Meta分析中的效应修饰
- Author:
Fengqi LIU
1
;
Zhirong YANG
;
Shanshan WU
;
Houyu ZHAO
;
Siyan ZHAN
;
Feng SUN
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系，北京 100191
- Keywords:
Meta-analysis;
Effect modification;
Subgroup analysis;
Meta-regression
- From:
Chinese Journal of Epidemiology
2024;45(1):148-154
- CountryChina
- Language:Chinese
-
Abstract:
This paper briefly introduces the definition, classification and significance of effect modification in epidemiological studies, summarizes the difference between effect modifier and confounders, and analyze the influence as well as the role of effect modification in epidemiological studies and Meta-analysis. In this paper, the possible scenarios of effect modification and related analysis strategy in Meta-analysis are indicated by graphics, aiming to arouse researchers' attention to effect modification. This paper also demonstrates how to identify and deal with effect modification in Meta-analysis through a study case of "Efficacy of sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes", and shows the analysis process and interpretation of results of subgroup analysis and Meta-regression methods respectively. The advantages and disadvantages of these two methods are summarized to provide reference for the method selection of future research.
