Association of Human Whole-blood NAD+Levels with Nabothian Cyst
- Author:
Ling XU
1
,
2
;
Xuan Yue WANG
;
Wei WANG
;
Xue FAN
;
Yu Xue CHEN
;
Yun Tian ZHOU
;
He Yu LIU
;
Ye YU
;
Fan YANG
;
Yu Zhen JU
;
Yong ZHOU
;
Liang Deng WANG
Author Information
- Keywords: Nicotinamide adenine dinucleotide; Nabothian cyst; Female; Risk factor
- From: Biomedical and Environmental Sciences 2024;37(5):471-478
- CountryChina
- Language:Chinese
- Abstract: Objective Little is known about the association between whole-blood nicotinamide adenine dinucleotide(NAD+)levels and nabothian cysts.This study aimed to assess the association between NAD+levels and nabothian cysts in healthy Chinese women. Methods Multivariate logistic regression analysis was performed to analyze the association between NAD+levels and nabothian cysts. Results The mean age was 43.0±11.5 years,and the mean level of NAD+was 31.3±5.3 μmol/L.Nabothian cysts occurred in 184(27.7%)participants,with single and multiple cysts in 100(15.0%)and 84(12.6%)participants,respectively.The total nabothian cyst prevalence gradually decreased from 37.4%to 21.6%from Q1 to Q4 of NAD+and the prevalence of single and multiple nabothian cysts also decreased across the NAD+quartiles.As compared with the highest NAD+quartile(≥34.4 μmol/L),the adjusted odds ratios with 95%confidence interval of the NAD+Q1 was 1.89(1.14-3.14)for total nabothian cysts.The risk of total and single nabothian cysts linearly decreased with increasing NAD+levels,while the risk of multiple nabothian cysts decreased more rapidly at NAD+levels of 28.0 to 35.0 μmol/L. Conclusion:Low NAD+levels were associated with an increased risk of total and multiple nabothian cysts.
