Study on the relationship between triglyceride glucose index and systemic immune- inflammation index based on natural population in Xi'an
10.3760/cma.j.cn112338-20230328-00187
- VernacularTitle:基于西安城市自然人群的甘油三酯葡萄糖乘积指数与系统免疫炎症指数的关联研究
- Author:
Yan HUANG
1
;
Ziping WANG
;
Hui JING
;
Yuxin TENG
;
Chacha SAMUEL
;
Yezhou LIU
;
Binyan ZHANG
;
Yuan SHEN
;
Qiang LI
;
Baibing MI
;
Jiaomei YANG
;
Hong YAN
;
Shaonong DANG
Author Information
1. 西安交通大学医学部公共卫生学院流行病与卫生统计学系，西安 710061
- Keywords:
Triglyceride glucose index;
Systemic immune-inflammation index;
Insulin resistance;
Inflammation;
Obesity
- From:
Chinese Journal of Epidemiology
2023;44(11):1762-1768
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between triglyceride glucose index (TyG) and body inflammation.Methods:The data were obtained from a baseline survey in population in Xi'an in natural population cohort study in northwest China established in 2018-2019. Based on TG and FPG, TyG/TyG-BMI was constructed to reflect insulin resistance (IR) in the body, and systemic immune-inflammation index (SII) reflecting inflammation in the body was constructed using neutrophil, lymphocyte, and platelet counts. A logistic regression model was used to explore the relationship between the TyG and the SII.Results:A total of 11 491 subjects were included in the analysis. After adjusting for covariates, each unit increase in the TyG increased the risk of high SII by 21% ( OR=1.21, 95% CI:1.12-1.30). The risk of high SII in the group with the TyG in Q4 was 1.34 times higher than that in the group Q1 ( OR=1.34, 95% CI:1.18-1.52). Both sensitivity analysis and subgroup analysis further confirmed the stability of the association between the TyG and the SII. In the population with a BMI ranging from 18.5 to 23.9 kg/m 2, for every unit increase in the TyG as a continuous variable, the risk for high SII increased by 31% ( OR=1.31, 95% CI:1.18-1.45). As a categorical variable, the risk for high SII in the Q4 group was 1.52 times higher than that in the Q1 group ( OR=1.52, 95% CI:1.27-1.83). In a population with BMIs ranging from 24.0 to 27.9 kg/m 2, for every unit increase in the TyG as a continuous variable, the risk for high SII increased by 20% ( OR=1.20, 95% CI:1.07-1.35), and there was no significant difference when it was a categorical variable. Conclusions:The increase in IR is closely related to the development of inflammation in the body, and BMI may regulate their relationship. Early prevention of elevated IR levels before overweight or obesity may have a positive effect on the control of inflammation in the body.
