Investigation of 2019-nCoV reinfection in previously infected people in Suzhou
10.3760/cma.j.cn112338-20230331-00199
- VernacularTitle:苏州市新型冠状病毒既往感染者再感染情况调查分析
- Author:
Yuanyuan ZHANG
1
;
Hui HANG
;
Qian XU
;
Cheng LIU
;
Yayun TAN
;
Pengwei CUI
;
Lin BAO
;
Hui LIU
;
Shanshan LU
;
Feng XU
;
Yuanyuan PANG
;
Ge TIAN
;
Jun ZHANG
;
Jie ZHU
;
Liling CHEN
Author Information
1. 苏州市疾病预防控制中心传染病防制科，苏州 215000
- Keywords:
2019-nCoV;
Reinfection
- From:
Chinese Journal of Epidemiology
2023;44(11):1756-1761
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the reinfection rate of 2019-nCoV in the previously infected population in Suzhou and compare the illness severity and prognosis of the reinfection cases with the first-time infection cases.Methods:A questionnaire survey was conducted in the persons with previous 2019-nCoV infection reported in Suzhou from January 22, 2020 to November 8, 2022 to collect the information about the incidence of reinfection of 2019-nCoV in this population from December 8, 2022 to January 18, 2023. The persons who were infected with 2019-nCoV for the first time were selected by marching the residence, age and gender at ratio of 1∶2 from 2019-nCoV infection community follow-up cohort of Suzhou. By χ2 test, the clinical symptoms and prognosis of the reinfection case and the first-time infection cases were compared. Results:The reinfection rate of 2019-nCoV was 13.01% (147/1 130) in Suzhou. No reinfection was found within 1-6 months after the first-time infection, the rate of reinfection was 10.59% (95/897) in those with interval of 7-12 months between the reinfection and the first-time infection and 45.61% (52/114) in those with the interval ≥24 months. The lowest reinfection rate was 9.09% (1/11) in those who had completed 4 doses of 2019-nCoV vaccination. The main symptoms of the reinfection cases were similar to those of the first-time infection cases. Except for dry cough, nausea/poor appetite and other symptoms, there were significant differences in other clinical symptoms between the two groups ( P<0.05). In the reinfection cases, fever had shorter duration with lower body temperature. The hospital visit rate in the reinfection cases was 4.08% (6/147), lower than that in the cases with the first-time infection (11.56%, 34/294). The time for negative nucleic acid (antigen) test result and recovery from illness after the reinfection were shorter than those after the first-time infection. Conclusions:Reinfection occurred in some people who had been infected with 2019-nCoV. The interval between the reinfection and the first-time infection and the completion of the 4 doses of booster vaccination were the factors influencing the reinfection rate. The hospital visit rate in the reinfection cases was lower than that in the cases with the first-time infection. The reinfection had similar symptoms and shorter illness duration compared with the first-time infection.
