Application of target trail emulation in real world: a case study of effect of statins on mortality in diabetes patients
10.3760/cma.j.cn112338-20230301-00115
- VernacularTitle:模拟目标试验在真实世界中的应用：他汀类药物对糖尿病患者死亡率的影响
- Author:
Ruizhe WANG
1
;
Lijing XI
;
Xueke YANG
;
Chaoyue KU
;
Binbin WU
;
Man DAI
;
Zhiguang PING
Author Information
1. 郑州大学公共卫生学院流行病与卫生统计学系，郑州 450001
- Keywords:
Target trail emulation;
Real world study;
Observational research
- From:
Chinese Journal of Epidemiology
2023;44(9):1480-1485
- CountryChina
- Language:Chinese
-
Abstract:
Target trail emulation is an observational research method, which can use real-world data (such as observational data and historical data) to carry out research design according to the design principles of randomized controlled trials (RCT) when RCT cannot be carried out. The intervention group and the control group were classified by simulating random grouping. Finally a high-reliable conclusion similar to RCT can be obtained. This paper summarizes the basic concepts and application process of target trail emulation based on the effect of statins on the prognosis of myocardial infarction in diabetic patients to provide reference for the application of this method in real world.
