Epidemiological characteristics of mpox epidemic in Guangzhou
10.3760/cma.j.cn112338-20230627-00398
- VernacularTitle:广州市猴痘疫情流行病学特征分析
- Author:
Ruonan ZHEN
1
;
Wenzhe SU
;
Yunjing WEN
;
Shiyun LUO
;
Xinlong LIAO
;
Zhiyong TAN
;
Yefei LUO
;
Zhigang HAN
;
Jianxiong XU
;
Biao DI
;
Pengzhe QIN
Author Information
1. 广州市疾病预防控制中心，广州 510440
- Keywords:
Mpox;
Epidemiological characteristic
- From:
Chinese Journal of Epidemiology
2023;44(9):1421-1425
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the epidemiological characteristics of mpox epidemic in Guangzhou and provide scientific evidence for the prevention and control of the disease.Methods:Based on the mpox surveillance system in Guangzhou, suspected mpox cases with fever and rash were reported by local hospitals at all levels to centers for disease control and prevention in Guangzhou for sampling, investigation and diagnosis. Descriptive epidemiological analysis was conducted on the clinical characteristics and treatment of the mpox cases and positive detection rate reported in Guangzhou as of 24:00 on June 23. Whole genome sequencing of the virus isolates was performed using Illumina Miniseq high-throughput sequencing platform.Results:The first mpox case in Guangzhou was reported on June 10 in 2023. As of 24:00 on June 23, a total of 25 confirmed mpox cases were reported. All the mpox cases were men with a M( Q1, Q3) of 32 (26, 36) years, the majority of the cases were MSM (96.0%). The main clinical features were rash (100.0%, 25/25), lymphadenectasis (100.0%, 25/25) and fever (52.0%, 13/25). Rash usually occurred near the genitals (88.0%, 22/25). The close contacts, mainly family members (40.4%, 23/57), showed no similar symptoms, such as fever or rash. The positive rate of mpox virus in household environment samples was 30.5%. The analyses on 3 complete gene sequences of mpox virus indicated that the strains belonged to West African type Ⅱb clade, B.1.3 lineage. Conclusions:Hidden transmission of mpox virus had occurred in MSM in Guangzhou. However, the size of affected population is relatively limited, and the possibility of wide spread of the virus is low.
