Biosafety risk of laboratory-acquired infection and countermeasures based on human factors
10.3760/cma.j.cn112338-20230214-00075
- VernacularTitle:基于人为因素实验室获得性感染风险与生物安全应对策略
- Author:
Kunlan ZUO
1
;
Tao JIANG
;
Zongzhen WU
;
Yuanyuan GUO
;
Huan LIU
Author Information
1. 中国科学技术大学人文与社会科学学院，合肥 230026
- Keywords:
Laboratory-acquired infection;
Human factors;
Risk;
Biosafety
- From:
Chinese Journal of Epidemiology
2023;44(8):1309-1315
- CountryChina
- Language:Chinese
-
Abstract:
Biosafety of pathogenic microbiology laboratories generally highlights the use of protective equipment, procedures, and operating practices to protect personnel and the environment from potentially hazardous biological materials. Under the current complex situation where traditional and non-traditional biosafety issues coexist, laboratory-acquired infection (LAI) of pathogenic microorganisms may cause illness, disability and even death. Pathogenic microorganisms may also be carried to the surrounding environment, causing community infection, which should be taken seriously. Analysis of LAI cases helps to understand the causes of exposure and learn lessons from post-exposure prophylaxis to be prepared and even prevent problems before they happen. Human factors cause most LAIs, laboratory activities related to aerosolization, laboratory activities related to sharps materials, low ability of personnel performing the work, and deficiencies in laboratory facilities or management are the four main factors. This study focuses on the human factors that lead to LAI, combined with confirmed cases, discusses the biosafety risks of pathogenic microorganism laboratories, reviews the development and evolution of biosafety laboratories and the current protection measures for experimenters, and accordingly puts forward countermeasures and suggestions.
