Association between different obesity measurement indexes and serum C-reactive protein in adult women
10.3760/cma.j.cn112338-20221122-00992
- VernacularTitle:不同肥胖测量指标与成年女性血清C反应蛋白的关联研究
- Author:
Xingyue LI
1
;
Huifang YANG
;
Jinyu XIAO
;
Yu HAO
;
Bin XU
;
Xueyao WU
;
Xunying ZHAO
;
Tianpei MA
;
Liang LYU
;
Wanting FENG
;
Jiayuan LI
Author Information
1. 四川大学华西公共卫生学院/华西第四医院，成都 610041
- Keywords:
Obesity;
C-reactive protein;
Body mass index;
Adiposity
- From:
Chinese Journal of Epidemiology
2023;44(8):1251-1256
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association of different obesity measurement indexes on serum C-reactive protein (CRP) in Chinese adult women.Methods:The data were obtained from baseline and follow-up surveys of the urban Breast Cancer Screening Program in Shuangliu District, Chengdu. A total of 441 adult women were included in the study. A questionnaire survey, physical examination, and laboratory testing were conducted on the subjects. Multivariate logistic regression model, two-level mixed effects logistic regression model, and restricted cubic spline method were used to investigate the linear and nonlinear correlation between different obesity measurement indexes and serum CRP in adult women.Results:For every 1 unit increase in BMI, waist circumference (WC), and adiposity, the risk of elevated serum CRP or exacerbation of chronic low-grade inflammation in adult women increased by 16.5%, 5.0%, and 11.1% ( P<0.05), respectively. Both BMI and adiposity were nonlinear correlated with serum CRP. Using BMI=24.0 kg/m 2 as the reference point, serum CRP level increased with the increase of BMI when BMI >24.0 kg/m 2. Using adiposity=30% as the reference point, serum CRP level increased with the increase of adiposity when adiposity >30%. Conclusions:Overall, obesity reflected by BMI had the strongest association with serum CRP in adult women, followed by body fat content reflected by adiposity, and central obesity reflected by WC had the weakest association with CRP. Adult women with BMI >24.0 kg/m 2 or adiposity >30% are at high risk for obesity-related inflammatory manifestations.
