Association analysis between sex hormone levels and all-cause mortality in Hainan female centenarians
10.3760/cma.j.cn112338-20221130-01015
- VernacularTitle:海南女性百岁老人性激素水平与全因死亡的关联分析
- Author:
Qiao ZHU
1
;
Shimin CHEN
;
Haowei LI
;
Rongrong LI
;
Shanshan YANG
;
Shengshu WANG
;
Yali ZHAO
;
Chaoxue NING
;
Miao LIU
;
Yao HE
Author Information
1. 解放军总医院海南医院中心实验室，三亚 572013
- Keywords:
Sex hormones;
All-cause mortality;
Female centenarian
- From:
Chinese Journal of Epidemiology
2023;44(8):1245-1250
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution characteristics of sex hormones and their relationship with all-cause mortality in Hainan female centenarians.Methods:All the subjects were from China Hainan Centenarian Cohort Study. A total of 717 female centenarians were included in the final analysis. Kaplan-Meier method was used to draw the survival curve, and Cox proportional hazard regression was used to analyze the relationship between sex hormones and survival time.Results:The M( Q1, Q3) of estradiol and progesterone among female centenarians was 32.60 (18.40, 58.70) pmol/L and 0.62 (0.32, 1.01) nmol/L. The estradiol (pmol/L) and progesterone (nmol/L) in the survival and death groups were 26.65 vs.37.80, 0.54 vs.0.69, respectively, with statistical differences ( P<0.05). Cox multivariate analysis showed that estradiol and progesterone were significantly associated with death ( P<0.05), the hazard ratio ( HR) of estradiol Q4 was 1.58 (95% CI: 1.17-2.15), and the HR of progesterone Q3 was 1.53 (95% CI: 1.10-2.12), HR for Q4 was 1.63 (95% CI: 1.15-2.32). Subgroup and cross-analysis showed that estradiol was statistically significant with hypertension, diabetes, and low high-density lipoprotein cholesterol ( P<0.05), and progesterone interacted with diabetes ( P=0.016), while testosterone interacted with low high-density lipoprotein cholesterol ( P=0.034). Conclusion:It is suggested that the estrogen levels of female centenarians in Hainan were associated with a higher mortality risk and an increased risk of cardiovascular metabolic disease (such as diabetes, hypertension, and abnormal lipid metabolism).
