Study on the associations of meeting intensive systolic blood pressure control goals with risk for incident cardiovascular and cerebrovascular diseases among the adult hypertensive patients in China
10.3760/cma.j.cn112338-20230317-00156
- VernacularTitle:中国成年高血压患者达到强化收缩压控制目标与心脑血管疾病发生风险的关联研究
- Author:
Haiming YANG
1
;
Yuxuan ZHAO
;
Jun LYU
;
Canqing YU
;
Yu GUO
;
Pei PEI
;
Huaidong DU
;
Junshi CHEN
;
Zhengming CHEN
;
Dianjianyi SUN
;
Liming LI
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系/重大疾病流行病学教育部重点实验室，北京 100191
- Keywords:
Hypertension;
Cardiovascular and cerebrovascular diseases;
Intensive systolic blood pressure control
- From:
Chinese Journal of Epidemiology
2023;44(8):1175-1182
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the associations of meeting intensive systolic blood pressure (SBP) control goals with risk for incident cardiovascular and cerebrovascular diseases among the adult hypertensive patients in China.Methods:We used data from adult hypertensive patients from the China Kadoorie Biobank. logistic regression models evaluated the influencing factors of meeting intensive and standard SBP control goals. Cox proportional hazard models evaluated the associations between meeting intensive vs. standard SBP control goals and risk for incident cardiovascular and cerebrovascular diseases.Results:A total of 3 628 hypertensive patients who reported continuous medication use were included in this study, of which 5.0% of the participants met the goals of intensive SBP control (≤130 mmHg). Participants with higher educational attainment ( OR=2.36,95% CI: 1.32-4.04), healthier diet ( OR=2.09,95% CI: 1.45-2.96), daily intake of fresh fruit ( OR=1.67,95% CI: 1.17-2.36) and combination treatment ( OR=1.82,95% CI: 1.03-3.09) were more likely to meet intensive SBP control goal after adjustment of age, sex and urban/rural areas. During an average follow-up of (10.0±3.7) years, 1 278 cases of composite cardiovascular outcome were recorded. This study did not find a statistical correlation between achieving the goal of enhanced SBP control and the occurrence of composite cardiovascular and cerebrovascular outcomes ( HR=0.89, 95% CI: 0.63-1.25). For major adverse cardiovascular events (MACE), cerebrovascular diseases, stroke, and ischemic stroke, we observed a trend of decrease in risk of outcomes with more intensive SBP control (trend test P<0.05). Conclusions:We observed decreased risk for MACE and cerebrovascular diseases with more intensive SBP control. However, there was no significant risk reduction for cardiovascular and cerebrovascular diseases when meeting the intensive SBP control goal, compared to the standard SBP control goal.
