A review on using real-world data to study the impact of Enterovirus A71 vaccine on the incidence of hand, foot and mouth disease
10.3760/cma.j.cn112338-20220417-00310
- VernacularTitle:基于真实世界数据研究肠道病毒A71型疫苗对手足口病发病影响的研究进展
- Author:
Zheng ZHAO
1
;
Jie HONG
;
Qing SU
;
Jiaqi HUANG
;
Xi CHEN
;
Jiaxu LE
;
Yi HU
;
Zhaorui CHANG
;
Zhijie ZHANG
Author Information
1. 复旦大学公共卫生学院流行病学与卫生统计学教研室，上海 200032
- Keywords:
Vaccine;
Hand, foot and mouth disease;
Real-world study;
Enterovirus A71
- From:
Chinese Journal of Epidemiology
2023;44(2):310-316
- CountryChina
- Language:Chinese
-
Abstract:
Hand, foot and mouth disease (HFMD) is a widespread infectious disease mainly affecting children aged five and under. In China, the current epidemic situation of HFMD remains severe, with a persistently high and increasing incidence rate, causing a substantial disease burden. A monovalent vaccine against Enterovirus A71 (EV-A71), the most common cause of severe and fatal HFMD cases, has been available in China since 2016. Although randomized controlled trials established the vaccine's efficacy among research subjects, this may not reflect the impact under "real world" conditions in the general population. Therefore, based on a systematic literature search, this paper comprehensively reviewed and analyzed relevant studies based on real-world data and collected real-world evidence about the EV-A71 vaccine on the controlling HFMD incidence. It was found that the real-world study of the EV-A71 vaccine on HFMD was few; most were limited to a province or city; there is no study comprehensively considered other important influencing factors in addition to immunization, such as temperature, relative humidity, the age structure of the population, gross domestic product, etc. The progress of using real-world data to study the impact of the EV-A71 vaccine on HFMD reviewed in this study is helpful to have a clear and comprehensive understanding of the status quo and will provide guidance and reference for future studies to assess the short-term and long-term effects of EV-A71 vaccine and other vaccines.
