The relationship between chronic obstructive pulmonary disease and bone mineral density in Chinese adults
10.3760/cma.j.cn112338-20220425-00341
- VernacularTitle:中国成年人慢性阻塞性肺疾病与骨密度的相关性分析
- Author:
Kexiang SHI
1
;
Yunqing ZHU
;
Canqing YU
;
Jun LYU
;
Yu GUO
;
Pei PEI
;
Ling YANG
;
Huaidong DU
;
Yiping CHEN
;
Junshi CHEN
;
Zhengming CHEN
;
Liming LI
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系，北京 100191
- Keywords:
Chronic obstructive pulmonary disease;
Global Initiative for Chronic Obstructive Lung Disease grade;
Bone mineral density
- From:
Chinese Journal of Epidemiology
2023;44(2):221-228
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between chronic obstructive pulmonary disease (COPD) and bone mineral density (BMD) in Chinese male and female adults.Methods:Linear regression models were used to analyze the correlations between COPD and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) grade concerning bone mineral density indices, including broadband ultrasound attenuation, speed of sound, and stiffness index, based on data from the second resurvey of China Kadoorie Biobank.Results:Among 23 876 participants, the prevalence of COPD was 34.3% (3 130/9 125) in males and 23.2% (3 416/14 751) in females. Compared with healthy males and healthy females, broadband ultrasound attenuation, speed of sound, and stiffness index decreased in males and females with COPD, with β values (95% CI) of -0.87 (-1.37- -0.36), -3.42 (-5.42- -1.43) and -1.53 (-2.34- -0.71) in males and -0.66 (-1.09- -0.23), -2.24 (-3.92- -0.55), -1.06 (-1.71- -0.40) in females, respectively. The decrease was greater in males than females (all P for interaction <0.05). The GOLD grade of COPD was inversely correlated with all the three indices in a dose-response manner (all P for trend <0.001). Subgroup analysis showed that patients with COPD had a greater decrease in BMD in males whose ages were ≥ 60 years, males who were less physically active, and participants who were not overweight or obese. Conclusions:COPD was negatively correlated with bone mineral density. More attention should be paid to the bone mineral density of patients with COPD, especially those with older age, less physical activity, or lower BMI.
