A metabolomic approach to investigate the etiology of cardiometabolic diseases: recent advances and applications
10.3760/cma.j.cn112338-20220614-00531
- VernacularTitle:代谢组学在心血管代谢疾病病因研究中的应用进展
- Author:
Si CHENG
1
;
Yuanjie PANG
;
Jun LYU
;
Canqing YU
;
Dianjianyi SUN
;
Liming LI
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系，北京 100191
- Keywords:
Metabolomics;
Cardiometabolic disease;
Diabetes
- From:
Chinese Journal of Epidemiology
2023;44(1):157-164
- CountryChina
- Language:Chinese
-
Abstract:
Metabonomics is a life science research that uses high-throughput omics technology to identify and quantify all metabolites and has been widely used to examine the etiology of cardiometabolic diseases in recent years. As a significant component of systemic epidemiology, metabolomics provides insights into disease etiology from the perspective of metabolic changes. Research questions of metabolomics include assessing the associations of metabolites with cardiometabolic diseases, discovering novel biomarkers, and constructing risk prediction models. This article reviews the applications of metabolomics in the etiological research on type 2 diabetes, cardiovascular disease, hypertension, and subclinical atherosclerosis, as well as recent advance and future perspectives.
