Study on effect of intensive intervention on negative spouses in HIV sero-discordant couples in Butuo County of Liangshan Yi Autonomous Prefecture, Sichuan Province
10.3760/cma.j.cn112338-20220607-00505
- VernacularTitle:四川省凉山彝族自治州布拖县HIV感染单阳家庭阴性配偶干预效果评价
- Author:
Lu SHI
1
;
Xianzhi LI
;
Wen YANG
;
Yihui YANG
;
Liao FENG
;
Jike ERSHA
;
Jianhua ZHANG
;
Rongsheng LUAN
Author Information
1. 四川大学华西公共卫生学院/华西第四医院，成都 610041
- Keywords:
HIV/AIDS;
Sero-discordant couples;
Evaluation;
Intervention
- From:
Chinese Journal of Epidemiology
2023;44(1):139-144
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of intensive intervention on negative spouses in sero-discordant couples.Methods:From December 2019 to December 2020, all HIV sero-discordant couples in seven townships in Butuo County of Liangshan were enrolled and divided into intensive intervention group and routine intervention group. Both intensive intervention and routine intervention were conducted for one year. Baseline survey and follow-up were conducted respectively with a questionnaire survey and a serological testing in HIV sero-discordant couples in the two groups at 6 th month before and after the interventions. Multivariable Cox proportional hazards model and difference-in-difference model were used to evaluate the effect of the intensive intervention. Results:A total of 899 sero-discordant couples were enrolled (393 of intensive intervention group and 506 of routine intervention group), in whom 806 completed the follow up survey (349 of intensive intervention group and 457 of routine intervention group). Compared with routine intervention, intensive intervention had no effect to improve the correct answer rate of an AIDS related question in negative spouses ( P>0.05), but could improve their awareness of AIDS related knowledge ( β=1.40, P=0.008). Compared with routine intervention, intensive intervention could reduce the frequency of sex between HIV sero-discordant couples ( β=-0.73, P=0.021), and increase the frequency of condom use ( β=0.19, P=0.007), but had no effect to decrease the positive conversion rate in negative spouses ( β=-0.61, OR=0.55,95% CI:0.18-1.66, P=0.294). Conclusions:The intensive interventions could improve the awareness of AIDS related knowledge in negative spouses in sero-disordant couples and promote their safe sexual behavior, but had no effect to decrease the positive conversion in negative spouses. It is necessary to continue the intensive intervention and follow up to evaluate the effects of the intervention.
