Effect of nutritional status on all-cause death in Hainan centenarians: a prospective cohort study
10.3760/cma.j.cn112338-20220413-00291
- VernacularTitle:海南百岁老人营养状况对全因死亡影响的前瞻性队列研究
- Author:
Yang SONG
1
;
Shengshu WANG
;
Jianwei WANG
;
Shaohua LIU
;
Shimin CHEN
;
Xuehang LI
;
Yali ZHAO
;
Jing LI
;
Qiao ZHU
;
Chaoxue NING
;
Jianhua WANG
;
Miao LIU
;
Yao HE
Author Information
1. 解放军总医院第二医学中心老年医学研究所，衰老及相关疾病研究北京市重点实验室，国家老年疾病临床医学研究中心，北京 100853
- Keywords:
Centenarian;
Nutrition status;
All-cause death;
Mortality rate
- From:
Chinese Journal of Epidemiology
2023;44(1):122-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between nutritional status and all-cause death in the centenarians in Hainan Province.Methods:Based on the survey data of China Hainan Centenarian Cohort Study from 2014 to 2021, a total of 1 002 Hainan centenarians with complete baseline data were included in this study, and their survival status and death outcome were surveyed. According to the Mini Nutritional Assessment Short-Form (MNA-SF), the centenarians were divided into three groups: well-nourished (12-14), at risk of malnutrition (8-11), and malnutrition (0-7). The survival status of the centenarians was evaluated by Kaplan-Meier curve. Cox proportional hazards regression model was used to assess the association between nutritional status and all-cause death.Results:After the follow-up on May 31, 2021, we had found that 522 centenarians died, with an all-cause mortality rate of 52.10% (522/1 002). Compared with the well-nourished group, the average life lost caused by malnutrition was 0.62 years. Kaplan-Meier survival analysis showed that all-cause mortality rate was higher in the malnourished centenarians than in other groups ( χ2=16.45, P<0.001). Multivariate Cox proportional hazards regression model showed that the risk of all-cause mortality rate in malnourished centenarians was higher than that in well-nourished centenarians ( HR=1.65, 95% CI: 1.18-2.31). Subgroup analysis found that the association in female centenarians was more significant. Conclusions:Malnutrition was associated with a high risk of all-cause death in Hainan centenarians. It is suggested that we should timely evaluate and pay attention to the impact of nutritional status of centenarians on their health and longevity, and death, especially in the female elderly.
