Effect of depressive symptom on the death and longevity in Hainan centenarians: a prospective cohort study
10.3760/cma.j.cn112338-20220413-00288
- VernacularTitle:海南百岁老人抑郁症状对死亡与寿命影响的前瞻性队列研究
- Author:
Shimin CHEN
1
;
Shengshu WANG
;
Yang SONG
;
Shaohua LIU
;
Xuehang LI
;
Zhiqiang LI
;
Haowei LI
;
Rongrong LI
;
Jianhua WANG
;
Shanshan YANG
;
Yali ZHAO
;
Jing LI
;
Qiao ZHU
;
Chaoxue NING
;
Miao LIU
;
Yao HE
Author Information
1. 解放军总医院第二医学中心老年医学研究所，衰老及相关疾病研究北京市重点实验室，国家老年疾病临床医学研究中心，北京 100853
- Keywords:
Centenarian;
Depression;
All-cause death;
Cohort study
- From:
Chinese Journal of Epidemiology
2023;44(1):99-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the association between depression and all-cause death in centenarians in Hainan Province.Methods:Based on China Hainan Centenarian Cohort Study, 1 002 centenarians with integral data were included in the baseline survey, follow up was conducted to collect the information about their survival status and death outcome. Depression was evaluated by the 15-item Geriatric Depression Scale (GDS-15) and based on the evaluation scores, the mental status of the centenarians was classified as: severe depressive disorder (MDD; score ≥10), minor depressive disorder (MnDD; score 6-9), and normal status (score ≤5). Multivariable-adjusted Cox proportional hazards regression models was used to estimate the hazard ratios ( HRs) and 95% CIs. Results:As of May 31 st, 2021, a total of 522 deaths had been reported, with a mortality density of 152.39/1 000 person-years and a median follow up time M( Q1, Q3) of 4.16 (1.31, 5.04) years, in the centenarians. After adjusting the factors of socio-demographic characteristics and lifestyle, multivariate Cox regression analysis showed that the risk of all-cause mortality increased by 3.1% for every 1-point increase in GDS-15 score ( HR=1.031, 95% CI: 1.002-1.061). Compared with centenarians with normal status, the risk of mortality in the centenarians with MDD increased by 35.9% ( HR=1.359, 95% CI: 1.023-1.806), the centenarians with MDD had an average 1.94 years of life lost. Among the female centenarians, the risk of mortality in MnDD group and MDD group increased by 29.3% ( HR=1.293, 95% CI: 1.053-1.590) and 42.3% ( HR=1.423, 95% CI: 1.047-1.935) compared with normal group, those with MDD had an average 1.71 years of life lost. Conclusions:Depression was related to the increased risk of all-cause death and life lost in the centenarians in Hainan.
