Association between parathyroid hormone and all-cause death in Hainan centenarians: a prospective cohort study
10.3760/cma.j.cn112338-20220414-00292
- VernacularTitle:海南百岁老人甲状旁腺激素水平与全因死亡关联的前瞻性队列研究
- Author:
Rongrong LI
1
;
Shengshu WANG
;
Yang SONG
;
Shaohua LIU
;
Xuehang LI
;
Shimin CHEN
;
Zhiqiang LI
;
Haowei LI
;
Shanshan YANG
;
Jianhua WANG
;
Yali ZHAO
;
Jing LI
;
Qiao ZHU
;
Chaoxue NING
;
Miao LIU
;
Yao HE
Author Information
1. 解放军总医院第二医学中心老年医学研究所，衰老及相关疾病研究北京市重点实验室，国家老年疾病临床医学研究中心，北京 100853
- Keywords:
Centenarian;
Parathyroid hormone;
All-cause death;
Cohort study
- From:
Chinese Journal of Epidemiology
2023;44(1):92-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between parathyroid hormone (PTH) and all-cause death in the centenarians in Hainan Province.Methods:The study was based on China Hainan Centenarian Cohort Study, a total of 1 002 centenarians were included in the baseline survey, the follow up was conducted to collect the information about their death outcome. The association between baseline PTH level and all-cause death was analyzed by Cox proportional risk regression model using continuous variables, dichotomous variables, and quad variables as independent variables of the centenarians.Results:As of May 31 st, 2021, a total of 522 centenarians had died in the follow up period, the median of the follow up time was 4.16 (1.31,5.04) years, and the mortality rate was 52.10%. After fully adjusting the covariates, the multiple Cox proportional hazards regression analyses showed that the risk of all-cause death increased by 3.7% for every 10 pg/ml increase in PTH value, the HR was 1.037 (95% CI: 1.007-1.067) in all the centenarians. The risk of death in the centenarians in the highest PTH group was 1.458 (95% CI: 1.131-1.878) times higher than that in the lowest PTH group. Conclusions:Higher parathyroid hormone level was associated with the elevated risk for all-cause death in the centenarians in Hainan. PTH can be used as a reference index for the prediction of the death risk of long-lived elderly in community.
