Design and practice of China Northwest General Population Cohort
10.3760/cma.j.cn112338-20220927-00822
- VernacularTitle:西北区域自然人群队列建设与实践
- Author:
Shaonong DANG
1
;
Jianghong DAI
;
Yuhong ZHANG
;
Xinhua WANG
;
Fuchang MA
;
Hong YAN
Author Information
1. 西安交通大学公共卫生学院流行病与卫生统计学系，西安 710061
- Keywords:
Chronic and non-communicable disease;
Cohort study;
General population;
Northwestern China
- From:
Chinese Journal of Epidemiology
2023;44(1):14-20
- CountryChina
- Language:Chinese
-
Abstract:
The prevention and control of chronic and non-communicable diseases is an important public health problem in China. The general environment in the northwestern China is unique, and the health and disease status of local population is distinctive. In order to meet the urgent need for in-depth research of the causes, mechanisms and prognosis of chronic and non-communicable diseases in this area, a general population cohort in Shaanxi Province, Gansu Province and Qinghai Province, Ningxia Hui Autonomous Region and Xinjiang Uygur Autonomous Region was established during 2017-2019. A total of 117 644 general individuals aged 35-74 years in the multi-ethnic groups (Han, Hui, Uygur, Kazak and Tibetan) were recruited according to the special ecological environment, population size and ethnic distribution. The baseline information about individual exposure, environment and society were collected. More than 900 000 biological samples, including whole blood, plasma, serum and buffy coat, were collected and stored at -80 ℃ in standardized biobank. The long-term observation has started in forms of routine monitoring and active follow-up. The average age of the cohort members was 52.43 years, and 70 391 cohort members were women (59.8%). There were some differences in socio-economic status and lifestyle among different ethnic groups. Although the cohort members in different ethnic groups had similar health status, different characteristics still existed. The cohort can serve as a platform for in-depth research of the relationship between major chronic and non-communicable diseases and environment, people's lifestyle and genetic factors, and the research results can be used as important epidemiological evidence for clarifying the causes of chronic and non-communicable diseases and long-term health hazards in different ethnic groups in this area and reference for the national chronic and non-communicable disease prevention and control. This paper briefly introduces the design and practice of general population cohort in northwestern China.
