Research progress on the epidemiological distribution and influencing factors of autosomal mosaic chromosomal alteration
10.3760/cma.j.cn112338-20220715-00632
- VernacularTitle:常染色体嵌合变异的流行病学分布及其影响因素研究进展
- Author:
Mingyu SONG
1
;
Yuxuan ZHAO
;
Yuting HAN
;
Canqing YU
;
Jun LYU
;
Liming LI
;
Dianjianyi SUN
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系，北京 100191
- Keywords:
Somatic mosaicism;
Mosaic chromosomal alteration;
Ageing;
Influencing factors
- From:
Chinese Journal of Epidemiology
2022;43(12):2026-2029
- CountryChina
- Language:Chinese
-
Abstract:
Somatic mosaicism is defined as the occurrence and accumulation of somatic mutations in humans, and mosaic chromosomal alterations (mCA) are recognized as one of the aging phenotypes due to their impact on genome integrity. With the coming acceleration of global population aging, understanding the prevalence and influencing factors of mCA will help to explore the "genomic instability" of human aging and its biological mechanisms and provide the scientific basis for the primary prevention of age-related diseases. This review aims to summarize the epidemiological distribution and influencing factors of autosomal mCA in peripheral blood based on previous large-scale population-based studies.
