Immunohistochemical study on sweat gland tumors with monoclonal antibodies against S-100 subunits.
- Author:
Kyung Jeh SUNG
;
Kwang Hyun CHO
;
Ho Seok SUH
;
Jee Ho CHOI
;
Jai Kyoung KOH
- Publication Type:Original Article
- Keywords:
Immunohistochemical staining;
S-100a;
S-100p;
Sweat gland tumor;
Langerhans cell
- MeSH:
Acrospiroma;
Adenoma;
Antibodies;
Antibodies, Monoclonal*;
Carcinoma, Adenoid Cystic;
Dendritic Cells;
Eccrine Porocarcinoma;
Immunoenzyme Techniques;
Langerhans Cells;
Poroma;
S100 Proteins;
Skin;
Sweat Glands*;
Sweat*;
Syringoma
- From:Korean Journal of Dermatology
1992;30(4):446-453
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
S-100 protein is a mixture of three proteins, that is, S-100 ao(aa), S-100 a(ab) and, S- 100 b(bb). Twenty-two case, of sweat gland tumors were stained with immunoperoxidase technique (ABC method) for the presence of S-100a and b-subunit. Four syringomas, four eccrine poromas, two eccrine porocarcinomas, two ecerine spirdeiomas, one papillary eccrine adenoma, three clear cell hidradenomas, three mixed tumr rs of the skin, two papillary syringocystadenomas, and one cylindroma were included. All specimens were formalin-fixed and paraffin-embedded. The results were as follows : 1) The staining patterns of anti-S-100a and b-protein antibodies we e simillar to those of anti-S-100 protein antibody except in eccrine poroma and porocare nomal. 2) In eccrine poroma and porocarcinoma, scattered S-100-positive dendritic cells within tumor cell nests were stained by S-100-protein antibody (3/6), but not by anti-S-100a protein antibody. S-100p is present in normal Langerhans cells. Therefore this finding suggests that these cells niay be Langerhans cells
