Relationship between Chinese dietary guidelines compliance index for pregnant women and congenital heart disease in offspring
10.3760/cma.j.cn112338-20220429-00358
- VernacularTitle:孕期妇女膳食指南依从性指数与子代先天性心脏病的关系
- Author:
Qianqian CHANG
1
;
Shaonong DANG
;
Hong YAN
;
Lingxia ZENG
;
Jiaomei YANG
Author Information
1. 西安交通大学医学部公共卫生学院流行病与卫生统计学教研室，西安 710061
- Keywords:
Congenital heart disease;
Chinese dietary guidelines compliance index for pregnant women;
Diet quality
- From:
Chinese Journal of Epidemiology
2022;43(12):1979-1985
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between the Chinese dietary guidelines compliance index for pregnant women (CDGCI_PW) and congenital heart disease (CHD) in offspring.Methods:In a hospital-based case-control study conducted in Xi'an, Shaanxi province, semi-quantitative food frequency questionnaires were used to investigate the diets of pregnant women throughout pregnancy. The modified CDGCI_PW score was used to evaluate dietary quality during pregnancy, logistic regression was applied to analyze the relationship between CDGCI_PW score and offspring CHD, and the ROC curve was adopted to construct the prediction model of CDGCI_PW for offspring CHD.Results:A total of 1 422 subjects were enrolled, including 474 in the case group and 948 in the control group. The CDGCI_PW score in the case group M ( Q1, Q3) was 46.0 (26.0, 65.0) lower than that in the control group, which was 60.0 (40.0, 77.0). The difference between the two groups was significant ( P<0.001). Compared with those in the Q1 of CDGCI_PW, the offspring in the Q2, Q3, and Q4 of CDGCI_PW had a lower risk of total CHD ( OR=0.60, 95% CI: 0.43-0.83; OR=0.64, 95% CI: 0.45-0.89; OR=0.29, 95% CI: 0.19-0.44), with the trend test P<0.001. The risk of total CHD was reduced by 17% ( OR=0.83, 95% CI: 0.79-0.88) when 10 points increased the CDGCI_PW score. The area under curve predicted by constructing the ROC curve was 0.793 (95% CI: 0.768-0.818), and at the maximum of the Youden index, the sensitivity was 0.740, and the specificity was 0.725. Conclusion:This study suggests that improving dietary quality during pregnancy may reduce the risk of CHD in offspring.
