Preconception reproductive health and birth outcome cohort in Chongqing: the cohort profile
10.3760/cma.j.cn112338-20220219-00134
- VernacularTitle:重庆市孕前生殖健康与出生结局队列：设计简介与建设概况
- Author:
Qing CHEN
1
;
Wenzheng ZHOU
;
Niya ZHOU
;
Huan YANG
;
Yimeng WANG
;
Haiyan ZHANG
;
Qiuhong LI
;
Nianrong WANG
;
Hongyan CHEN
;
Lin AO
;
Jinyi LIU
;
Ziyuan ZHOU
;
Hua ZHANG
;
Wei ZHOU
;
Hongbo QI
;
Jia CAO
Author Information
1. 陆军军医大学/第三军医大学军事预防医学系毒理学研究所，重庆 400038
- Keywords:
Birth cohort;
Exposomics;
Spontaneous pregnancy;
Preconception;
Semen
- From:
Chinese Journal of Epidemiology
2022;43(7):1134-1139
- CountryChina
- Language:Chinese
-
Abstract:
Birth cohort is an important platform to study the effect of early-life exposure on health outcome, but large cohorts to investigate the effect of preconception exposure, especially paternal exposure, on reproductive health and birth outcome are limited. The Preconception Reproductive Health and Birth Outcome Cohort (PREBIC) is a prospective birth cohort study which pays equal attention to the contribution of environmental, psychological, behavioral as well as other factors to reproductive health and adverse birth outcomes in both men and women in Chongqing, China. PREBIC started in 2019 and plans to recruit 20 800 reproductive-age couples with child-bearing willingness. Followed up was conducted to understand the conception status of the women within two years. Women in pregnancy would be visited at first, second, third trimesters and after delivery. The offspring would be monitored until 2 years old to understand the incidences of preterm birth, low birth weight, birth defects, neurodevelopmental disorders and other outcomes. Related information and biospecimen collections (including semen, peripheral blood, urine, placenta, umbilical cord, cord blood and oral swab) were scheduled in each period. By January 2022, PREBIC had recruited 8 698 participants from all 38 districts in Chongqing. The goal of PREBIC is to establish one of the largest prospective preconception birth cohorts covering both men and women, which might provide a unique insight to understand the effects of the full reproductive cycle on reproductive health and adverse outcomes, with especial emphasis on preconception exposures.
