The Effect of Intravenous Lipo-Prostaglandin E1 Injectioin in a Rat Foraminal Stenosis Model.
- Author:
Hye Kyoung YOON
1
;
Pyung Bok LEE
;
Jin Soo HAN
;
Sang Hyun PARK
;
Seung Yoon LEE
;
Yang Hyun KIM
;
Yong Chul KIM
;
Sang Chul LEE
Author Information
- Publication Type:Original Article
- Keywords: hyperalgesia; lipo-PGE(1); spinal stenosis
- MeSH: Alprostadil; Animals; Constriction, Pathologic*; Diagnosis-Related Groups; Estrogens, Conjugated (USP); Humans; Hyperalgesia; Male; Neuralgia; Platelet Aggregation; Rats*; Rats, Sprague-Dawley; Spinal Stenosis; Stainless Steel; Veins
- From:The Korean Journal of Pain 2007;20(1):15-20
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: Lipo-prostaglandin E1 (Lipo-PGE1) has vasodilating and platelet aggregation inhibitory characteristics and it has been used as a treatment for patients with blood flow dysfunction disease. Based on the mechanisms of lumbar spinal stenosis, including veno congestion, neuro-ischemia and mechanical compression, we aimed to study whether intravenous Lipo-PGE1 injection has any therapeutic effect on hyperalgesia in a rat foraminal stenosis model. METHODS: In this study, twenty male Sprague-Dawley rats were divided into the control (n = 10) and Lipo-PGE(1)(n = 10) groups. A small stainless steel rod was inserted into the L5-6 intervertebral foramen to induce intervertebral foramen stenosis and chronic DRG compression. In the Lipo-PGE1 group, 0.15micron g/kg of Lipo-PGE(1) were injected intravenously via a tail vein for 10 days starting from the 3rd day after operation. Behavioral testing for mechanical and thermal hyperalgesia was performed for 3 weeks after the injections. RESULTS: From the 10th day after Lipo-PGE(1) injection, the rats in the experimental group showed significant recovery of their mechanical threshold, and this effect was maintained for 3 weeks. No significant differences of the thermal hyperalgesia were observed between the two groups. CONCLUSIONS: These findings suggest that intravenously injected Lipo-PGE1 may be effective for alleviating neuropathic pain, which isthe main symptom of spinal stenosis, by improving the blood flow dysfunction.
