Associations between sleep status and risk for kidney stones in Chinese adults: a prospective cohort study
10.3760/cma.j.cn112338-20210930-00760
- VernacularTitle:中国成年人睡眠状况与肾结石风险的前瞻性队列研究
- Author:
Han WANG
1
;
Yiqian ZHANG
;
Canqing YU
;
Yu GUO
;
Pei PEI
;
Junshi CHEN
;
Zhengming CHEN
;
Jun LYU
;
Liming LI
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系，北京 100191
- Keywords:
Insomnia;
Sleep duration;
Snoring;
Kidney stones;
Cohort studies;
Chinese
- From:
Chinese Journal of Epidemiology
2022;43(7):1002-1009
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the associations between sleep status and the risk for kidney stone in Chinese adults.Methods:This study used baseline and long-term follow-up data of China Kadoorie Biobank. After excluding those with self-reporting of diagnosed chronic kidney disease and cancer and those with extreme values of sleep duration at baseline survey, 501 701 participants were included in this study. The information about their sleep status were collected, including insomnia symptoms, daytime sleepiness, nap habit, snoring and sleep duration. The sleep score was constructed based on insomnia symptoms, daytime sleepiness, and sleep duration, ranging from 0 to 3. Cox proportional hazards regression models were used to evaluate the association of sleep status with the risk for kidney stone, including individual sleep factors and combined sleep score.Results:During the follow-up for average (10.7±2.2) years, 12 381 cases of kidney stone were recorded for the first time. Compared with participants without insomnia symptoms, the multivariable-adjusted HR of kidney stone in those with difficulty falling asleep and waking up early were 1.12 (95% CI: 1.06-1.18) and 1.06 (95% CI: 1.00-1.12), respectively. There was no statistically significant association of kidney stone risk with sleeping pill use, daytime sleepiness, nap habit, or snoring. Compared with participants with sleep duration ≥7 hours per day, the HR of kidney stone in those with sleep duration <7 hours per day was 1.13 (95% CI: 1.08-1.18). Compared with participants with sleep score of 3 (highest sleep quality), the HR of kidney stone in those with sleep score of 2, 1, and 0 were 1.08 (95% CI: 1.03-1.13), 1.16 (95% CI: 1.10-1.23), and 1.19 (95% CI: 1.03-1.37), respectively. Conclusion:In China, adults with insomnia symptoms or short sleep duration have increased risk for kidney stone.
