The effect of red blood cell folate on the prognosis of high-risk human papillomavirus infection: a community-based cohort study
10.3760/cma.j.cn112338-20210408-00291
- VernacularTitle:红细胞叶酸对高危型人乳头瘤病毒感染转归影响的前瞻性队列研究
- Author:
Caihong WU
1
;
Ruixin PEI
;
Jiaxin YAN
;
Ling DING
;
Yuanjing LYU
;
Li SONG
;
Jie WANG
;
Dan MENG
;
Hong LIU
;
Zhuo QI
;
Min HAO
;
Jintao WANG
Author Information
1. 山西医科大学公共卫生学院流行病学教研室，太原 030001
- Keywords:
Red blood cell folate;
High-risk human papillomavirus;
Prognosis
- From:
Chinese Journal of Epidemiology
2021;42(12):2174-2178
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of red blood cell folate on the prognosis of high-risk human papillomavirus (HR-HPV) infection .Methods:A total of 564 participants with low-grade cervical intraepithelial neoplasias (CINⅠ) were selected from the community-based married women cohort established in 2014. The general baseline information and factors related to HPV infection were collected. Meanwhile, HPV genotyping and levels of folate were measured. The subjects were divided into different levels of exposure group according to the folate levels and followed up for 24 months to observe the changes of HR-HPV infection status. There were four changes, including persistent infection, infection turned negative, from negative to positive and constant negative by comparing HR-HPV infection status at baseline and follow-up to 24 months.Results:483 participators completed 24 months of follow-up observation, with a follow-up rate of 85.64% (483/564). The rates of persistent infection, infection turned negative, from negative to positive, and the constant negative were 52.45% (75/143), 47.55% (68/143), 19.71% (67/340), 80.29% (273/340), respectively. Our results demonstrated that the risk of persistent infection (a RR=2.50, 95% CI: 1.55-4.02) and from negative to positive (a RR=4.55, 95% CI: 2.52-8.23) in the low level of folate were significantly higher than that in the high level of folate, especially the risk of homotype persistent infection (a RR=2.72, 95% CI: 1.51-4.90). The risk of persistent infection (trend χ2=20.62, P<0.001), from negative to positive (trend χ2=31.76, P<0.001), persistent homotypic infection (trend χ2=20.09, P<0.001) increased with the decrease of red blood cell folate level. On the contrary, no similar results were found in persistent heterotypic infection. Conclusions:A low level of red blood cell folate could increase the risk of HR-HPV persistent infection and from negative to positive. In women with HR-HPV infection, the risk of persistent homotypic infection is higher.
