Evaluation of screening strategies of multidrug-resistant tuberculosis among pulmonary tuberculosis patients of the different risk levels
10.3760/cma.j.cn112338-20210125-00063
- VernacularTitle:基于肺结核患者耐药风险的筛查策略对耐多药结核病发现效果的评价
- Author:
Huijuan CHEN
1
;
Xubin ZHENG
;
Yun WANG
;
Jinlan LI
;
Biao XU
Author Information
1. 贵州省疾病预防控制中心结核病防治研究所，贵阳 550004
- Keywords:
Multidrug-resistant;
Tuberculosis;
Population attributable risk proportion;
Screening strategy
- From:
Chinese Journal of Epidemiology
2021;42(12):2164-2169
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the detection of MDR-TB and XDR-TB patients and to provide evidence for further improvement of MDR-TB and XDR-TB screening strategy.Methods:Patients who were under drug resistance surveillance, registered and reported by the TB Management Information System of the Chinese Disease Prevention and Control Information System from 2012 to 2019 and resided in Guizhou province were retrospectively analyzed. The contribution of five high-risk subgroups to detection of MDR/XDR-TB were evaluated using population attributable risk proportion (PARP).Results:Of the 18 506 cases under drug resistance surveillance, patients who were male, aged between 25 and 54 years, with drug-resistant TB or with MDR/XDR-TB accounted for 68.65% (12 705/18 506), 47.69% (8 826/18 506), 15.90% (2 943/18 506) or 5.42% (1 003/18 506), respectively. Five high-risk subgroups made significant contributions to the detection of MDR/XDR-TB with a PARP of 57.00%. Specifically, the PARP were 21.70%, 19.49%, 11.90% and 2.30% for patients that were relapse and return, failed initial treatment, chronic/retreatment failure and smear-positive at the end of the second or third month, respectively. The detection rate of MDR/XDR-TB in high-risk groups was 15.89% (578/3 637) while in low-risk groups was 2.86% (425/14 869).Conclusions:Number of patients under drug resistance surveillance and the detection of MDR/XDR-TB trended to increase in Guizhou province from 2012 to 2019. The detection rate of MDR/XDR-TB in high-risk groups was higher than low-risk groups.
