A retrospective cohort study of the effects of the adverse childhood experience on chronic diseases of middle-aged and elderly
10.3760/cma.j.cn112338-20201223-01435
- VernacularTitle:童年期不良经历对中老年人患慢性病影响的回顾性队列研究
- Author:
Jiajia LI
1
;
Shiqi LIN
;
Jilei WU
;
Qi YU
;
Lijun PEI
Author Information
1. 北京大学人口研究所/北京大学中国人口健康与发展研究中心 100871
- Keywords:
Adverse childhood experience;
Chronic disease;
Retrospective cohort study
- From:
Chinese Journal of Epidemiology
2021;42(10):1804-1808
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the adverse childhood experience (ACE) effects on the risk of chronic diseases among middle-aged and elderly.Methods:A retrospective cohort study was conducted using the China Health and Retirement Longitudinal Study data. We used life history study data in 2014 as baseline data and data of chronic diseases of middle-aged and elderly in 2015 as outcomes. A zero-inflated negative-binominal model was used to estimate the incidence rate ratio ( IRR) for the association between ACE and chronic diseases. Results:Compared with the less than 4 points of ACE exposure in childhood, individuals with ACE exposure 4-, 6- and ≥9 were associated an increased risk of chronic disease, adjusted IRR (95% CI), 1.10(1.04-1.16), 1.18 (1.13-1.25), 1.34 (1.27-1.42), respectively, with a significant dose-response relationship that chronic diseases risks increase parallel with the increase of ACE exposure. Conclusions:ACE might serve as one of the critical risk factors of chronic diseases in middle-aged elderly. It's of public health significance for early screening and intervention of ACE, reducing the incidence of chronic diseases, and improving middle-aged and older adults' quality of life and health.
